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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY.

OVCA2 is a putative serine-hydrolase. Performing protein profiling in human tumour cell lines, OVCA2 was detected in DAOY medulloblastoma cells as a high abundance protein. The protein was unambiguously identified by 2D gel-electrophoresis and MALDI-MS and MS/MS, its presence was confirmed by western blotting. Immunohistochemistry revealed expression in medulloblastoma and predominantly in oligodendrocytes. Computational approaches predicted functional motifs and domains, interaction with apoptosis-related protein BAG and 3D structure. In addition to the presence of OVCA2 in medulloblastoma, it was furthermore detectable in three out of 10 human tumour cell-lines as a high abundance protein probably suggesting a role in the tumour biology.[1]

References

  1. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. Azizi, A.A., Gelpi, E., Yang, J.W., Rupp, B., Godwin, A.K., Slater, C., Slavc, I., Lubec, G. Cancer Lett. (2006) [Pubmed]
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