Disease relevance of OVCA2

• We show that OVCA2 mRNA and protein are ubiquitously expressed and that they are downregulated in the lung cancer cell line Calu-6 after treatment with RA and 4HPR [1].
• In addition to the presence of OVCA2 in medulloblastoma, it was furthermore detectable in three out of 10 human tumour cell-lines as a high abundance protein probably suggesting a role in the tumour biology [2].

High impact information on OVCA2

• Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13 [3].
• FSH3p shares significant sequence similarity with the product of the human tumor suppressor gene OVCA2 [4].
• Our results are in contrast to a previous report and show that OVCA2, not OVCA1 mRNA and protein, is downregulated in response to RA and 4HPR [1].
• OVCA2 is downregulated and degraded during retinoid-induced apoptosis [1].

Chemical compound and disease context of OVCA2

• Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY [2].

Anatomical context of OVCA2

• Northern blot analysis reveals that OVCA1 and OVCA2 mRNA were expressed in normal surface epithelial cells of the ovary, but the level of this transcript is significantly reduced or is undetectable in 92% (11/12) of the ovarian tumors and tumor cell lines analyzed [3].
• In addition, we observed that OVCA2 protein is proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL60 [1].

References