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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Clozapine-induced agranulocytosis in a Native American: HLA typing and further support for an immune-mediated mechanism.

BACKGROUND: Approximately 30% of schizophrenic patients defined as treatment refractory significantly improve with clozapine. However, clozapine produces agranulocytosis in approximately 1% to 2% of patients in the United States. The mechanism of clozapine-induced agranulocytosis has not been established, but evidence suggests an immune-mediated mechanism. METHOD: Human leukocyte antigen (HLA) typing was performed in a native American with clozapine-induced agranulocytosis. RESULTS: Our findings support previous observations of a role of the HLA-B16, DR4, DQw3 haplotype in predicting susceptibility to agranulocytosis in clozapine-treated patients. CONCLUSION: We suggest that HLA typing of clozapine candidates may be useful for predicting the risk for clozapine-induced agranulocytosis.[1]

References

  1. Clozapine-induced agranulocytosis in a Native American: HLA typing and further support for an immune-mediated mechanism. Pfister, G.M., Hanson, D.R., Roerig, J.L., Landbloom, R., Popkin, M.K. The Journal of clinical psychiatry. (1992) [Pubmed]
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