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MeSH Review


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Disease relevance of Agranulocytosis


Psychiatry related information on Agranulocytosis


High impact information on Agranulocytosis

  • CONCLUSIONS: In low-risk patients with cancer who have fever and granulocytopenia, oral therapy with ciprofloxacin plus amoxicillin-clavulanate is as effective as intravenous therapy [8].
  • Agranulocytosis occurred in 1.2 percent of the patients given 60 mg of vesnarinone per day and 0.2 percent of those given 30 mg of vesnarinone [9].
  • The risk of agranulocytosis associated with deferiprone may restrict its administration to patients who are unable or unwilling to use deferoxamine [10].
  • Cohen syndrome is an autosomal recessive disorder characterized by mental and motor retardation, short stature, microcephaly, several dysmorphic features, major ocular symptoms and granulocytopenia [11].
  • Patients randomly assigned to receive s-BACOP subsequently received five identical cycles, whereas those assigned to receive esc-BACOP received 40 mg of doxorubicin per square meter on days 1 and 8 of five subsequent cycles if granulocytopenia (< 1000 cells per cubic millimeter) had not developed during the first cycle [12].

Chemical compound and disease context of Agranulocytosis


Biological context of Agranulocytosis


Anatomical context of Agranulocytosis


Gene context of Agranulocytosis


Analytical, diagnostic and therapeutic context of Agranulocytosis


  1. Psoas abscess localization by gallium scan in aplastic anemia. Oster, M.W., Gelrud, L.G., Lotz, M.J., Herzig, G.P., Johnston, G.S. JAMA (1975) [Pubmed]
  2. Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma. Werblin, T.P., Pollack, I.P., Liss, R.A. JAMA (1979) [Pubmed]
  3. Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis. Murray, H.W., Cervia, J.S., Hariprashad, J., Taylor, A.P., Stoeckle, M.Y., Hockman, H. J. Clin. Invest. (1995) [Pubmed]
  4. High frequency of agranulocytosis in breast-cancer patients treated with levamisole. Teerenhovi, L., Heinonen, E., Gröhn, P., Klefström, P., Mehtonen, M., Tiilikainen, A. Lancet (1978) [Pubmed]
  5. Cimetidine, lupus erythematosus, and granulocytopenia. Littlejohn, G.O., Urowitz, M.B. Ann. Intern. Med. (1979) [Pubmed]
  6. Oculocutaneous albinism, immunodeficiency, hematological disorders, and minor anomalies: a new autosomal recessive syndrome? Kotzot, D., Richter, K., Gierth-Fiebig, K. Am. J. Med. Genet. (1994) [Pubmed]
  7. Recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) after bone marrow transplantation. Link, H., Freund, M., Kirchner, H., Stoll, M., Schmid, H., Bucsky, P., Seidel, J., Schulz, G., Schmidt, R.E., Riehm, H. Behring Inst. Mitt. (1988) [Pubmed]
  8. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. Kern, W.V., Cometta, A., De Bock, R., Langenaeken, J., Paesmans, M., Gaya, H. N. Engl. J. Med. (1999) [Pubmed]
  9. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. Cohn, J.N., Goldstein, S.O., Greenberg, B.H., Lorell, B.H., Bourge, R.C., Jaski, B.E., Gottlieb, S.O., McGrew, F., DeMets, D.L., White, B.G. N. Engl. J. Med. (1998) [Pubmed]
  10. Iron-chelation therapy with oral deferipronein patients with thalassemia major. Olivieri, N.F., Brittenham, G.M., Matsui, D., Berkovitch, M., Blendis, L.M., Cameron, R.G., McClelland, R.A., Liu, P.P., Templeton, D.M., Koren, G. N. Engl. J. Med. (1995) [Pubmed]
  11. Cohen syndrome gene assigned to the long arm of chromosome 8 by linkage analysis. Tahvanainen, E., Norio, R., Karila, E., Ranta, S., Weissenbach, J., Sistonen, P., de la Chapelle, A. Nat. Genet. (1994) [Pubmed]
  12. Escalated as compared with standard doses of doxorubicin in BACOP therapy for patients with non-Hodgkin's lymphoma. Meyer, R.M., Quirt, I.C., Skillings, J.R., Cripps, M.C., Bramwell, V.H., Weinerman, B.H., Gospodarowicz, M.K., Burns, B.F., Sargeant, A.M., Shepherd, L.E. N. Engl. J. Med. (1993) [Pubmed]
  13. Cimetidine therapy in a patient with metiamide-induced agranulocytosis. Fleischer, D., Samloff, I.M. N. Engl. J. Med. (1977) [Pubmed]
  14. Fenoprofen and agranulocytosis. Simon, S.D., Kosmin, M. N. Engl. J. Med. (1978) [Pubmed]
  15. Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. Arnaout, M.A., Hakim, R.M., Todd, R.F., Dana, N., Colten, H.R. N. Engl. J. Med. (1985) [Pubmed]
  16. Tolmetin and agranulocytosis. Sakai, J., Joseph, M.W. N. Engl. J. Med. (1978) [Pubmed]
  17. Propylthiouracil-induced agranulocytosis in four patients previously treated with the drug. Shiran, A., Shechner, C., Dickstein, G. JAMA (1991) [Pubmed]
  18. Association between the DRB1*08032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease. Tamai, H., Sudo, T., Kimura, A., Mukuta, T., Matsubayashi, S., Kuma, K., Nagataki, S., Sasazuki, T. Ann. Intern. Med. (1996) [Pubmed]
  19. Clozapine-induced agranulocytosis in a Native American: HLA typing and further support for an immune-mediated mechanism. Pfister, G.M., Hanson, D.R., Roerig, J.L., Landbloom, R., Popkin, M.K. The Journal of clinical psychiatry. (1992) [Pubmed]
  20. HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis. Corzo, D., Yunis, J.J., Yunis, E.J., Howard, A., Lieberman, J.A. The Journal of clinical psychiatry. (1994) [Pubmed]
  21. On the possible mechanisms and predictability of clozapine-induced agranulocytosis. Pisciotta, A.V., Konings, S.A., Ciesemier, L.L., Cronkite, C.E., Lieberman, J.A. Drug safety : an international journal of medical toxicology and drug experience. (1992) [Pubmed]
  22. Expression of CD117 and CD11b in bone marrow can differentiate acute promyelocytic leukemia from recovering benign myeloid proliferation. Rizzatti, E.G., Garcia, A.B., Portieres, F.L., Silva, D.E., Martins, S.L., Falcão, R.P. Am. J. Clin. Pathol. (2002) [Pubmed]
  23. Brief intensive chemotherapy for metastatic non-small-cell lung cancer: a phase II study of the weekly CODE regimen. Murray, N., Osoba, D., Shah, A., Page, R., Karsai, H., Little, C. J. Natl. Cancer Inst. (1991) [Pubmed]
  24. Sulindac induced agranulocytosis and bone marrow culture. Romeril, K.R., Duke, D.S., Hollings, P.E. Lancet (1981) [Pubmed]
  25. Letter: Dilantin, agranulocytosis, and phagocytic marrow histiocytes. Tsan, M.F., Mehlman, D.J., Green, R.S., Bell, W.R. Ann. Intern. Med. (1976) [Pubmed]
  26. Response to granulocyte-macrophage colony-stimulating factor (GM-CSF) but not to G-CSF in a case of agranulocytosis associated with large granular lymphocyte (LGL) leukemia. Lamy, T., LePrise, P.Y., Amiot, L., Drenou, B., Fauchet, R., Genetet, N., Semana, G. Blood (1995) [Pubmed]
  27. Syndrome of neutrophil agranulocytosis, hypogammaglobulinemia, and thymoma. Degos, L., Faille, A., Housset, M., Boumsell, L., Rabian, C., Parames, T. Blood (1982) [Pubmed]
  28. Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. Mosyagin, I., Dettling, M., Roots, I., Mueller-Oerlinghausen, B., Cascorbi, I. Journal of clinical psychopharmacology. (2004) [Pubmed]
  29. Prostaglandin E2 mediates growth arrest in NFS-60 cells by down-regulating interleukin-6 receptor expression. de Silva, K.I., Daud, A.N., Deng, J., Jones, S.B., Gamelli, R.L., Shankar, R. Biochem. J. (2003) [Pubmed]
  30. Soluble tumour necrosis factor receptors, tumour necrosis factor and interleukin-6 in serum in granulocytopenic patients with fever. Steinshamn, S., Brekke, O.L., Waage, A. Br. J. Haematol. (1995) [Pubmed]
  31. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky, O., Meged, S., Loewenthal, R., Valevski, A., Weizman, A., Carp, H., Gazit, E. Tissue Antigens (2003) [Pubmed]
  32. Interleukin 6, but not tumour necrosis factor-alpha, is a good predictor of severe infection in febrile neutropenic and non-neutropenic children with malignancy. Abrahamsson, J., Påhlman, M., Mellander, L. Acta Paediatr. (1997) [Pubmed]
  33. Effect of CD34+ selection and various schedules of stem cell reinfusion and granulocyte colony-stimulating factor priming on hematopoietic recovery after high-dose chemotherapy for breast cancer. Somlo, G., Sniecinski, I., Odom-Maryon, T., Nowicki, B., Chow, W., Hamasaki, V., Leong, L., Margolin, K., Morgan, R., Raschko, J., Shibata, S., Tetef, M., Molina, A., Berenson, R.J., Forman, S.J., Doroshow, J.H. Blood (1997) [Pubmed]
  34. Studies on levamisole--induced agranulocytosis. Thompson, J.S., Herbick, J.M., Klassen, L.W., Severson, C.D., Overlin, V.L., Blaschke, J.W., Silverman, M.A., Vogel, C.L. Blood (1980) [Pubmed]
  35. Correction of infantile agranulocytosis (Kostmann's syndrome) by allogeneic bone marrow transplantation. Rappeport, J.M., Parkman, R., Newburger, P., Camitta, B.M., Chusid, M.J. Am. J. Med. (1980) [Pubmed]
  36. Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. Berenguer, J., Allende, M.C., Lee, J.W., Garrett, K., Lyman, C., Ali, N.M., Bacher, J., Pizzo, P.A., Walsh, T.J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  37. Genetic factors and risk of agranulocytosis from metamizol. Vlahov, V., Bacracheva, N., Tontcheva, D., Naumova, E., Mavrudieva, M., Ilieva, P., Michailova, A. Pharmacogenetics (1996) [Pubmed]
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