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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.

The Arabidopsis genome encodes 10 D-type cyclins (CYCD); however, their differential role in cell cycle control is not well known. Among them, CYCD4;2 is unique in the amino acid sequence; namely, it lacks the Rb-binding motif and the PEST sequence that are conserved in CYCDs. Here, we have shown that CYCD4;2 suppressed G1 cyclin mutations in yeast and formed a kinase complex with CDKA;1, an ortholog of yeast Cdc28, in insect cells. Hypocotyl explants of CYCD4;2 over-expressing plants showed faster induction of calli than wild-type explants on a medium containing lower concentration of auxin. These results suggest that CYCD4;2 has a promotive function in cell division by interacting with CDKA;1 regardless of the unusual primary sequence.[1]

References

  1. A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis. Kono, A., Ohno, R., Umeda-Hara, C., Uchimiya, H., Umeda, M. Plant Cell Rep. (2006) [Pubmed]
 
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