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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer.Cell Death and Differentiation (2006) 13, 861-872. doi:10.1038/sj.cdd.4401870; published online 10 February 2006.[1]


  1. Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Pasparakis, M., Luedde, T., Schmidt-Supprian, M. Cell Death Differ. (2006) [Pubmed]
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