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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease.

Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.[1]


  1. Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. Knizewski, L., Kinch, L., Grishin, N.V., Rychlewski, L., Ginalski, K. J. Virol. (2006) [Pubmed]
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