Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Alphaherpesvirinae

Osterhaus, A.D. et al., Knizewski, L. et al., Nigro, O. et al., Pomeranz, L.E. et al., Jacobs, L., et al.

Favoreel, Van Minnebruggen, Adriaensen, Nauwynck, Pomeranz, Reynolds, Hengartner,

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Disease relevance of Alphaherpesvirinae

Pseudorabies virus (PRV) is a herpesvirus of swine, a member of the Alphaherpesvirinae subfamily, and the etiological agent of Aujeszky's disease [1].
The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle [2].

High impact information on Alphaherpesvirinae

The US3 protein is a viral kinase that is conserved among the Alphaherpesvirinae [3].
Phylogenetic analysis of the GTHV DBP gene confirmed and substantiated that this novel Chelonian herpesvirus is closely related to the subfamily Alphaherpesvirinae [4].
Glycoprotein E of pseudorabies virus and homologous proteins in other alphaherpesvirinae [5].
The virus was tentatively characterized as a herpesvirus (seal herpesvirus: SeHV or phocid herpesvirus 1) on the basis of its characteristic morphology in electron microscopy, buoyant density in sucrose, sensitivity to ether and heat treatment and its antigenic relationship with other probable members of the Alphaherpesvirinae subfamily [6].

References

Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine. Pomeranz, L.E., Reynolds, A.E., Hengartner, C.J. Microbiol. Mol. Biol. Rev. (2005) [Pubmed]
Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. Knizewski, L., Kinch, L., Grishin, N.V., Rychlewski, L., Ginalski, K. J. Virol. (2006) [Pubmed]
Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread. Favoreel, H.W., Van Minnebruggen, G., Adriaensen, D., Nauwynck, H.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Sequencing and characterization of the full-length gene encoding the single-stranded DNA binding protein of a novel Chelonian herpesvirus. Nigro, O., Yu, G., Aguirre, A.A., Lu, Y. Arch. Virol. (2004) [Pubmed]
Glycoprotein E of pseudorabies virus and homologous proteins in other alphaherpesvirinae. Jacobs, L. Arch. Virol. (1994) [Pubmed]
The isolation and partial characterization of a highly pathogenic herpesvirus from the harbor seal (Phoca vitulina). Osterhaus, A.D., Yang, H., Spijkers, H.E., Groen, J., Teppema, J.S., van Steenis, G. Arch. Virol. (1985) [Pubmed]

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