Disease relevance of Gammaherpesvirinae

• Varicella-zoster virus (VZV) and Epstein-Barr virus (EBV) are important human pathogens which belong to different subfamilies of the herpesviruses: the Alpha- and Gammaherpesvirinae, respectively [1].
• The UL10 and UL49.5 genes of avian infectious laryngotracheitis virus (ILTV) encode putative envelope proteins which are conserved in Alpha, Beta, and Gammaherpesvirinae [2].
• Our data are consistent with the idea that methylated latent genomes are involved, after reactivation and productive replication, in the natural transmission cycle of most members of Gammaherpesvirinae and certain lymphotropic members of Alpha- and Betaherpesvirinae [3].

High impact information on Gammaherpesvirinae

• Open reading frame 31 (ORF31) is conserved among the Beta- and Gammaherpesvirinae subfamily, and there is no known mammalian homologue of this protein [4].
• Phylogenetic trees for both single-gene and concatenated alignments were evaluated thoroughly by maximum-likelihood methods, with each of the three herpesvirus subfamilies (the Alpha-, Beta-, and Gammaherpesvirinae) examined independently [5].
• These are new characteristics with regard to the general features of gB in the Gammaherpesvirinae subfamily [6].
• In all cases the three recognised subfamilies (Alpha-, Beta- and Gammaherpesvirinae), and major sublineages in each subfamily, were clearly distinguished, but within sublineages some finer details of branching were incompletely resolved [7].
• All sequences (gB, DPOL and TERM) showed a close relationship with the corresponding genes of the Gammaherpesvirinae [8].

Chemical compound and disease context of Gammaherpesvirinae

• Relative deficiency in CpG dinucleotides is a widespread but not unique feature of Gammaherpesvirinae genomes [3].

References