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A unique biotin carboxyl carrier protein in archaeon Sulfolobus tokodaii.

Biotin carboxyl carrier protein (BCCP) is one subunit or domain of biotin-dependent enzymes. BCCP becomes an active substrate for carboxylation and carboxyl transfer, after biotinylation of its canonical lysine residue by biotin protein ligase (BPL). BCCP carries a characteristic local sequence surrounding the canonical lysine residue, typically -M-K-M-. Archaeon Sulfolobus tokodaii is unique in that its BCCP has serine replaced for the methionine C-terminal to the lysine. This BCCP is biotinylated by its own BPL, but not by Escherichia coli BPL. Likewise, E. coli BCCP is not biotinylated by S. tokodaii BPL, indicating that the substrate specificity is different between the two organisms.[1]


  1. A unique biotin carboxyl carrier protein in archaeon Sulfolobus tokodaii. Li, Y.Q., Sueda, S., Kondo, H., Kawarabayasi, Y. FEBS Lett. (2006) [Pubmed]
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