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Arimitsu, J. et al.

IL-18 gene polymorphisms affect IL-18 production capability by monocytes.

We previously demonstrated a significant association between IL-18 gene polymorphism 105A/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105A/C and IL-18--137G/C was determined by PCR analyses. The IL-18 production by monocytes stimulated without or with LPS or A23187+PMA for 1day was measured by ELISA. The produced IL-18 spontaneously or in response to A23187+PMA by monocytes was significantly higher for volunteers with 105A/A genotype than with 105A/C genotype. Similarly, the production capability of IL-18 by monocytes from volunteers with -137G/G genotype was significantly higher than that with -137G/C genotype and significant linkage disequilibrium was observed between 105A/C and -137G/C polymorphism. Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma.[1]

References

IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Arimitsu, J., Hirano, T., Higa, S., Kawai, M., Naka, T., Ogata, A., Shima, Y., Fujimoto, M., Yamadori, T., Hagiwara, K., Ohgawara, T., Kuwabara, Y., Kawase, I., Tanaka, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

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