Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Soucek, K. et al.

Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications.

BACKGROUND: Multiple diverse posttranslational modifications of alpha-tubulin such as detyrosination, further cleavage of the penultimate glutamate residue (Delta2-tubulin), acetylation, and polyglutamylation increase the structural and functional diversity of microtubules. METHODS: Herein, we characterized the molecular profile of alpha-tubulin posttranslational modifications in normal human prostate epithelial cells (PrEC), immortalized normal prostate epithelial cells (PZ-HPV-7), androgen-dependent prostate cancer cells (LNCaP), transitional androgen-independent prostate cancer cells (LNCaP-cds and CWR22Rv1), and androgen-independent prostate cancer cells (PC3). RESULTS: Compared to PrEC and PZ-HPV-7 cells, all cancer cells exhibited elevated levels of detyrosinated and polyglutamylated alpha-tubulin, that was paralleled by decreased protein levels of tubulin tyrosine ligase ( TTL). In contrast, PrEC and PZ-HPV-7 cells expressed markedly higher levels of Delta2-tubulin. Whereas alpha-tubulin acetylation levels were generally equivalent in all the cell lines, PC3 cells did not display detectable levels of Ac-tubulin. CONCLUSION: These data may reveal novel biomarkers of prostate cancer and new therapeutic targets.[1]

References

Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications. Soucek, K., Kamaid, A., Phung, A.D., Kubala, L., Bulinski, J.C., Harper, R.W., Eiserich, J.P. Prostate (2006) [Pubmed]

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