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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Thalamic calcification in vitamin D receptor knockout mice.

Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification.[1]

References

  1. Thalamic calcification in vitamin D receptor knockout mice. Kalueff, A., Loseva, E., Haapasalo, H., Rantala, I., Keranen, J., Lou, Y.R., Minasyan, A., Keisala, T., Miettinen, S., Kuuslahti, M., Tuchimaa, P. Neuroreport (2006) [Pubmed]
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