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Gene Review

Vdr  -  vitamin D receptor

Mus musculus

Synonyms: 1,25-dihydroxyvitamin D3 receptor, Nr1i1, Nuclear receptor subfamily 1 group I member 1, VDR, Vitamin D3 receptor
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Disease relevance of Vdr


Psychiatry related information on Vdr

  • Here we report that VDR mutants display unaffected depressive-like behaviour, but show abnormal social behaviours, reduced social barbering and aggressiveness, impaired nest building and aberrant maternal (pup neglect, cannibalism) behaviours [7].

High impact information on Vdr


Chemical compound and disease context of Vdr


Biological context of Vdr


Anatomical context of Vdr


Associations of Vdr with chemical compounds


Physical interactions of Vdr


Regulatory relationships of Vdr


Other interactions of Vdr

  • Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism [27].
  • The skeletal response to pregnancy was comparable in wt and VDR-/- mice; duodenal CaBP-D9k concentrations increased during pregnancy in VDR-/- as in wt mice, but remained 40% lower than in wt mice [3].
  • Chromatin immunoprecipitation (ChIP) from liver nuclei showed that aging had no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha (retinoid X receptor) and PXR in mice injected with D(3) or PCN [28].
  • In addition, our data suggest that the 2% Ca diet promotes a vitamin D receptor-independent anabolic effect on bone formation and calcium absorption, leading to improved calcium balance even in the presence of high PTH levels [29].
  • In this report, we examined the VDR- and PXR-mediated gene induction of the phase II sulfotransferase Sult2A1 in the livers of 4-month- and 20-month-old mice [28].

Analytical, diagnostic and therapeutic context of Vdr


  1. The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. Kovacs, C.S., Woodland, M.L., Fudge, N.J., Friel, J.K. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  2. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Li, Y.C., Pirro, A.E., Amling, M., Delling, G., Baron, R., Bronson, R., Demay, M.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation. Rummens, K., van Cromphaut, S.J., Carmeliet, G., van Herck, E., van Bree, R., Stockmans, I., Bouillon, R., Verhaeghe, J. Pediatr. Res. (2003) [Pubmed]
  4. Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. Yu, X., Sabbagh, Y., Davis, S.I., Demay, M.B., White, K.E. Bone (2005) [Pubmed]
  5. Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Froicu, M., Zhu, Y., Cantorna, M.T. Immunology (2006) [Pubmed]
  6. Vitamin D receptor is essential for normal keratinocyte stem cell function. Cianferotti, L., Cox, M., Skorija, K., Demay, M.B. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  7. Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor gene. Kalueff, A.V., Keisala, T., Minasyan, A., Kuuslahti, M., Miettinen, S., Tuohimaa, P. Neurosci. Res. (2006) [Pubmed]
  8. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Yoshizawa, T., Handa, Y., Uematsu, Y., Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T., Arioka, K., Sato, H., Uchiyama, Y., Masushige, S., Fukamizu, A., Matsumoto, T., Kato, S. Nat. Genet. (1997) [Pubmed]
  9. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Pálmer, H.G., Larriba, M.J., García, J.M., Ordóñez-Morán, P., Peña, C., Peiró, S., Puig, I., Rodríguez, R., de la Fuente, R., Bernad, A., Pollán, M., Bonilla, F., Gamallo, C., de Herreros, A.G., Muñoz, A. Nat. Med. (2004) [Pubmed]
  10. Vitamin D receptor is required for dietary calcium-induced repression of calbindin-D9k expression in mice. Bolt, M.J., Cao, L.P., Kong, J., Sitrin, M.D., Li, Y.C. J. Nutr. Biochem. (2005) [Pubmed]
  11. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. Zhou, C., Assem, M., Tay, J.C., Watkins, P.B., Blumberg, B., Schuetz, E.G., Thummel, K.E. J. Clin. Invest. (2006) [Pubmed]
  12. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. Li, Y.C., Kong, J., Wei, M., Chen, Z.F., Liu, S.Q., Cao, L.P. J. Clin. Invest. (2002) [Pubmed]
  13. Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells. Swamy, N., Chen, T.C., Peleg, S., Dhawan, P., Christakos, S., Stewart, L.V., Weigel, N.L., Mehta, R.G., Holick, M.F., Ray, R. Clin. Cancer Res. (2004) [Pubmed]
  14. Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Zinser, G.M., Welsh, J. Carcinogenesis (2004) [Pubmed]
  15. Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Noda, M., Vogel, R.L., Craig, A.M., Prahl, J., DeLuca, H.F., Denhardt, D.T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  16. Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Kim, S., Yamazaki, M., Zella, L.A., Shevde, N.K., Pike, J.W. Mol. Cell. Biol. (2006) [Pubmed]
  17. Vitamin D physiology. Lips, P. Prog. Biophys. Mol. Biol. (2006) [Pubmed]
  18. Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. Panda, D.K., Miao, D., Bolivar, I., Li, J., Huo, R., Hendy, G.N., Goltzman, D. J. Biol. Chem. (2004) [Pubmed]
  19. Vitamin d inhibits the formation of prostatic intraepithelial neoplasia in nkx3.1; pten mutant mice. Banach-Petrosky, W., Ouyang, X., Gao, H., Nader, K., Ji, Y., Suh, N., Dipaola, R.S., Abate-Shen, C. Clin. Cancer Res. (2006) [Pubmed]
  20. Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. McCarthy, T.C., Li, X., Sinal, C.J. J. Biol. Chem. (2005) [Pubmed]
  21. 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. Kim, S., Shevde, N.K., Pike, J.W. J. Bone Miner. Res. (2005) [Pubmed]
  22. Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones. Swanson, C., Lorentzon, M., Conaway, H.H., Lerner, U.H. Endocrinology (2006) [Pubmed]
  23. Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives. Ferrara, J., McCuaig, K., Hendy, G.N., Uskokovic, M., White, J.H. J. Biol. Chem. (1994) [Pubmed]
  24. Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice. Rahman, A., Hershey, S., Ahmed, S., Nibbelink, K., Simpson, R.U. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  25. Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. Fujiki, R., Kim, M.S., Sasaki, Y., Yoshimura, K., Kitagawa, H., Kato, S. EMBO J. (2005) [Pubmed]
  26. Development and progression of alopecia in the vitamin D receptor null mouse. Bikle, D.D., Elalieh, H., Chang, S., Xie, Z., Sundberg, J.P. J. Cell. Physiol. (2006) [Pubmed]
  27. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Shimada, T., Yamazaki, Y., Takahashi, M., Hasegawa, H., Urakawa, I., Oshima, T., Ono, K., Kakitani, M., Tomizuka, K., Fujita, T., Fukumoto, S., Yamashita, T. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  28. Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: The role of a gene enhancer in the liver chromatin. Seo, Y.K., Chung, Y.T., Kim, S., Echchgadda, I., Song, C.S., Chatterjee, B. Gene (2007) [Pubmed]
  29. Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D9k mRNA. Song, Y., Kato, S., Fleet, J.C. J. Nutr. (2003) [Pubmed]
  30. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. Van Cromphaut, S.J., Rummens, K., Stockmans, I., Van Herck, E., Dijcks, F.A., Ederveen, A.G., Carmeliet, P., Verhaeghe, J., Bouillon, R., Carmeliet, G. J. Bone Miner. Res. (2003) [Pubmed]
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