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MeSH Review

Vitamin D Deficiency

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Disease relevance of Vitamin D Deficiency


Psychiatry related information on Vitamin D Deficiency


High impact information on Vitamin D Deficiency


Chemical compound and disease context of Vitamin D Deficiency


Biological context of Vitamin D Deficiency


Anatomical context of Vitamin D Deficiency


Gene context of Vitamin D Deficiency

  • These results suggest that chronic and profound hypocalcemia and/or vitamin D deficiency can stimulate endogenous PTHrP secretion via a negative feedback mechanism, although elevated iPTHrP does not normalize the decreased serum calcium levels [26].
  • OBJECTIVE: To improve understanding of the biochemical events in vitamin D-deficiency rickets (VDR) [27].
  • Aim: To examine the hypothesis that vitamin D status modulates the matrix metalloproteinase (MMP) system in a population with a high prevalence of vitamin D deficiency, a situation affecting susceptibility to CHD and diabetes [28].
  • METHODS: Circulating MMP2,9, the inhibitor TIMP-1 and C-reactive protein (CRP) were measured during studies of vitamin-D deficiency as a risk factor for type 2 diabetes and CHD in 171 healthy British Bangladeshi adults, free of known diabetes or major illness [28].
  • This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets [29].

Analytical, diagnostic and therapeutic context of Vitamin D Deficiency


  1. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I., Willnow, T.E. Cell (1999) [Pubmed]
  2. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. Pascussi, J.M., Robert, A., Nguyen, M., Walrant-Debray, O., Garabedian, M., Martin, P., Pineau, T., Saric, J., Navarro, F., Maurel, P., Vilarem, M.J. J. Clin. Invest. (2005) [Pubmed]
  3. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. Safadi, F.F., Thornton, P., Magiera, H., Hollis, B.W., Gentile, M., Haddad, J.G., Liebhaber, S.A., Cooke, N.E. J. Clin. Invest. (1999) [Pubmed]
  4. The multifactorial basis for hypocalcemia during sepsis. Studies of the parathyroid hormone-vitamin D axis. Zaloga, G.P., Chernow, B. Ann. Intern. Med. (1987) [Pubmed]
  5. Parathyroid hormone decreases renal vitamin D receptor expression in vivo. Healy, K.D., Vanhooke, J.L., Prahl, J.M., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Serum 25-OHD, vitamin A and vitamin E concentrations in healthy Finnish and Floridian women. Punnonen, R., Gillespy, M., Hahl, M., Koskinen, T., Notelovitz, M. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1988) [Pubmed]
  7. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Lips, P. Endocr. Rev. (2001) [Pubmed]
  8. Vitamin D deficiency inhibits pancreatic secretion of insulin. Norman, A.W., Frankel, J.B., Heldt, A.M., Grodsky, G.M. Science (1980) [Pubmed]
  9. Stay tuned to PXR: an orphan actor that may not be D-structive only to bone. Holick, M.F. J. Clin. Invest. (2005) [Pubmed]
  10. 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes. Bissonnette, M., Wali, R.K., Hartmann, S.C., Niedziela, S.M., Roy, H.K., Tien, X.Y., Sitrin, M.D., Brasitus, T.A. J. Clin. Invest. (1995) [Pubmed]
  11. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Raisz, L.G. J. Clin. Invest. (2005) [Pubmed]
  12. Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. Wassner, S.J., Li, J.B., Sperduto, A., Norman, M.E. J. Clin. Invest. (1983) [Pubmed]
  13. Bone disease in primary biliary cirrhosis: reversal of osteomalacia with oral 25-hydroxyvitamin D. Reed, J.S., Meredith, S.C., Nemchausky, B.A., Rosenberg, I.H., Boyer, J.L. Gastroenterology (1980) [Pubmed]
  14. Serum-25-hydroxyvitamin-D concentrations in adolescent boys. Ellis, G., Woodhead, J.S., Cooke, W.T. Lancet (1977) [Pubmed]
  15. Plasma creatinine and creatinine clearance in nutritional osteomalacia. Fonseca, V., Mohiuddin, J., Weerakoon, J., Boss, M., Mikhailidis, D.P., Dandona, P. Lancet (1984) [Pubmed]
  16. Vitamin D status and measurements of markers of bone metabolism in patients with small intestinal resection. Haderslev, K.V., Jeppesen, P.B., Sorensen, H.A., Mortensen, P.B., Staun, M. Gut (2003) [Pubmed]
  17. Intravenous calcitriol normalizes insulin sensitivity in uremic patients. Kautzky-Willer, A., Pacini, G., Barnas, U., Ludvik, B., Streli, C., Graf, H., Prager, R. Kidney Int. (1995) [Pubmed]
  18. Sex differences during the development of vitamin D deficiency in the rat: serum parathyroid hormone, calcitonin, calcium, and phosphorus. Thomas, M.L., Forte, L.R. Endocrinology (1981) [Pubmed]
  19. Somatomedin-C/insulin-like growth factor I and vitamin D-induced growth. Clark, S.A., D'Ercole, A.J., Toverud, S.U. Endocrinology (1986) [Pubmed]
  20. The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study. Klein, G.L., Wimalawansa, S.J., Kulkarni, G., Sherrard, D.J., Sanford, A.P., Herndon, D.N. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  21. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Cantorna, M.T., Zhu, Y., Froicu, M., Wittke, A. Am. J. Clin. Nutr. (2004) [Pubmed]
  22. The adenosine triphosphate-dependent calcium pump in rat small intestine: effects of vitamin D deficiency and cell isolation methods. van Corven, E.J., de Jong, M.D., van Os, C.H. Endocrinology (1987) [Pubmed]
  23. Influence of anthropometric parameters and biochemical markers of bone metabolism on quantitative ultrasound of bone in the institutionalized elderly. Krieg, M.A., Cornuz, J., Jacquet, A.F., Thiébaud, D., Burckhardt, P. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1998) [Pubmed]
  24. Relationship between calbindin-D28K levels in the A and B cells of the rat endocrine pancreas and the secretion of insulin and glucagon: influence of vitamin D3 deficiency and 1,25-dihydroxyvitamin D3. Bourlon, P.M., Faure-Dussert, A., Billaudel, B., Sutter, B.C., Tramu, G., Thomasset, M. J. Endocrinol. (1996) [Pubmed]
  25. Vitamin D3 stimulates calcium-45 uptake by isolated mouse islets in vitro. Frankel, B.J., Sehlin, J., Täljedal, I.B. Acta Physiol. Scand. (1985) [Pubmed]
  26. Increased serum immunoreactive parathyroid hormone-related protein levels in chronic hypocalcemia. Mune, T., Katakami, H., Morita, M., Noguchi, S., Ushiroda, Y., Matsukura, S., Yasuda, K., Miura, K. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  27. Pathophysiology of calcium metabolism in children with vitamin D-deficiency rickets. Kruse, K. J. Pediatr. (1995) [Pubmed]
  28. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? Timms, P.M., Mannan, N., Hitman, G.A., Noonan, K., Mills, P.G., Syndercombe-Court, D., Aganna, E., Price, C.P., Boucher, B.J. QJM : monthly journal of the Association of Physicians. (2002) [Pubmed]
  29. Parathyroid function in different stages of vitamin D deficiency rickets. Kruse, K., Bartels, H., Kracht, U. Eur. J. Pediatr. (1984) [Pubmed]
  30. Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet. Ammann, P., Laib, A., Bonjour, J.P., Meyer, J.M., Rüegsegger, P., Rizzoli, R. J. Bone Miner. Res. (2002) [Pubmed]
  31. Vitamin D deficiency among older women with and without disability. Semba, R.D., Garrett, E., Johnson, B.A., Guralnik, J.M., Fried, L.P. Am. J. Clin. Nutr. (2000) [Pubmed]
  32. Two vitamin D3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. I. Effect of CaBP 28K. Bouhtiauy, I., Lajeunesse, D., Christakos, S., Brunette, M.G. Kidney Int. (1994) [Pubmed]
  33. Influence of vitamin D status on insulin secretion and glucose tolerance in the rabbit. Nyomba, B.L., Bouillon, R., De Moor, P. Endocrinology (1984) [Pubmed]
  34. Neonatal primary hyperparathyroidism masked by vitamin D deficiency. Meeran, K., Husain, M., Puccini, M., Scott, H., Dionisi-Vici, C., Harvey, D.R., Lynn, J., Thakker, R.V. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
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