Cellular changes resulting from forced expression of glypican-3 in hepatocellular carcinoma cells.
Glypican-3 (GPC3) is a member of the glypican family, which encodes cell-surface heparan-sulfate proteoglycans, and is frequently upregulated in hepatocellular carcinoma ( HCC). We have recently reported that blocking endogenous GPC3 expression promotes the growth of HCC cell lines, suggesting that GPC3 plays a negative role in HCC cell proliferation. Here, we report that forced expression of GPC3 reduced the growth of HCC cells. We also found that FGF2- mediated cell proliferation was inhibited by GPC3. In addition, we observed that the adhesion of HCC cells to collagen type I and fibronectin was decreased by GPC3, whereas cellular migration and invasiveness were stimulated. Collectively, these results suggest that progression of hepatocellular carcinoma is associated with upregulation of GPC3.[1]References
- Cellular changes resulting from forced expression of glypican-3 in hepatocellular carcinoma cells. Kwack, M.H., Choi, B.Y., Sung, Y.K. Mol. Cells (2006) [Pubmed]
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