Gene Review:
GPC3 - glypican 3
Homo sapiens
Synonyms:
DGSX, GTR2-2, Glypican-3, Intestinal protein OCI-5, MXR7, ...
- Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Capurro, M., Wanless, I.R., Sherman, M., Deboer, G., Shi, W., Miyoshi, E., Filmus, J. Gastroenterology (2003)
- Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. Capurro, M.I., Shi, W., Sandal, S., Filmus, J. J. Biol. Chem. (2005)
- Highly sensitive detection of melanoma at an early stage based on the increased serum secreted protein acidic and rich in cysteine and glypican-3 levels. Ikuta, Y., Nakatsura, T., Kageshita, T., Fukushima, S., Ito, S., Wakamatsu, K., Baba, H., Nishimura, Y. Clin. Cancer Res. (2005)
- Expression of glypican 3 (GPC3) in embryonal tumors. Saikali, Z., Sinnett, D. Int. J. Cancer (2000)
- Inhibition of invasion and metastasis by glypican-3 in a syngeneic breast cancer model. Peters, M.G., Farías, E., Colombo, L., Filmus, J., Puricelli, L., Bal de Kier Joffé, E. Breast. Cancer. Res. Treat. (2003)
- Metastasis suppressors: basic and translational advances. Buchanan, C., Lago Huvelle, M.A., Peters, M.G. Curr. Pharm. Biotechnol. (2011)
- Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. Mahady, G.B. The Journal of cardiovascular nursing. (2002)
- Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Pilia, G., Hughes-Benzie, R.M., MacKenzie, A., Baybayan, P., Chen, E.Y., Huber, R., Neri, G., Cao, A., Forabosco, A., Schlessinger, D. Nat. Genet. (1996)
- The values and limitations of glypican-3 as a novel tumor marker for hepatocellular carcinoma from clinical and economic viewpoints. Moriguchi, H., Sato, C. Gastroenterology (2004)
- Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. De Cat, B., Muyldermans, S.Y., Coomans, C., Degeest, G., Vanderschueren, B., Creemers, J., Biemar, F., Peers, B., David, G. J. Cell Biol. (2003)
- The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. Kim, H., Xu, G.L., Borczuk, A.C., Busch, S., Filmus, J., Capurro, M., Brody, J.S., Lange, J., D'Armiento, J.M., Rothman, P.B., Powell, C.A. Am. J. Respir. Cell Mol. Biol. (2003)
- Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling. Sung, Y.K., Hwang, S.Y., Farooq, M., Kim, J.C., Kim, M.K. Exp. Mol. Med. (2003)
- Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. Veugelers, M., Cat, B.D., Muyldermans, S.Y., Reekmans, G., Delande, N., Frints, S., Legius, E., Fryns, J.P., Schrander-Stumpel, C., Weidle, B., Magdalena, N., David, G. Hum. Mol. Genet. (2000)
- Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Midorikawa, Y., Ishikawa, S., Iwanari, H., Imamura, T., Sakamoto, H., Miyazono, K., Kodama, T., Makuuchi, M., Aburatani, H. Int. J. Cancer (2003)
- Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene. Huber, R., Schlessinger, D., Pilia, G. Gene (1998)
- Glypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblast. Khan, S., Blackburn, M., Mao, D.L., Huber, R., Schlessinger, D., Fant, M. Histol. Histopathol. (2001)
- Oncofetal protein glypican-3 in testicular germ-cell tumor. Ota, S., Hishinuma, M., Yamauchi, N., Goto, A., Morikawa, T., Fujimura, T., Kitamura, T., Kodama, T., Aburatani, H., Fukayama, M. Virchows Arch. (2006)
- Expression pattern of glypican-3 (GPC3) during human embryonic and fetal development. Iglesias, B.V., Centeno, G., Pascuccelli, H., Ward, F., Peters, M.G., Filmus, J., Puricelli, L., de Kier Joffé, E.B. Histol. Histopathol. (2008)
- The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. Kawakami, T., Okamoto, K., Sugihara, H., Hattori, T., Reeve, A.E., Ogawa, O., Okada, Y. J. Urol. (2003)
- OCI-5/rat glypican-3 binds to fibroblast growth factor-2 but not to insulin-like growth factor-2. Song, H.H., Shi, W., Filmus, J. J. Biol. Chem. (1997)
- Frequent silencing of the GPC3 gene in ovarian cancer cell lines. Lin, H., Huber, R., Schlessinger, D., Morin, P.J. Cancer Res. (1999)
- Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells. Wichert, A., Stege, A., Midorikawa, Y., Holm, P.S., Lage, H. Oncogene (2004)
- Glypican-3 is overexpressed in human hepatocellular carcinoma. Sung, Y.K., Hwang, S.Y., Park, M.K., Farooq, M., Han, I.S., Bae, H.I., Kim, J.C., Kim, M. Cancer Sci. (2003)
- Developmental regulation of the soluble form of insulin-like growth factor-II/mannose 6-phosphate receptor in human serum and amniotic fluid. Xu, Y., Papageorgiou, A., Polychronakos, C. J. Clin. Endocrinol. Metab. (1998)
- The oncofetal protein glypican-3 is a novel marker of hepatic progenitor/oval cells. Grozdanov, P.N., Yovchev, M.I., Dabeva, M.D. Lab. Invest. (2006)
- Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways. Buchanan, C., Stigliano, I., Garay-Malpartida, H.M., Rodrigues Gomes, L., Puricelli, L., Sogayar, M.C., Bal de Kier Joffé, E., Peters, M.G. Breast. Cancer. Res. Treat. (2010)
- Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation. Stigliano, I., Puricelli, L., Filmus, J., Sogayar, M.C., Bal de Kier Joffé, E., Peters, M.G. Breast. Cancer. Res. Treat. (2009)
- GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. Veugelers, M., Vermeesch, J., Watanabe, K., Yamaguchi, Y., Marynen, P., David, G. Genomics (1998)
- Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. Cano-Gauci, D.F., Song, H.H., Yang, H., McKerlie, C., Choo, B., Shi, W., Pullano, R., Piscione, T.D., Grisaru, S., Soon, S., Sedlackova, L., Tanswell, A.K., Mak, T.W., Yeger, H., Lockwood, G.A., Rosenblum, N.D., Filmus, J. J. Cell Biol. (1999)
- Cellular changes resulting from forced expression of glypican-3 in hepatocellular carcinoma cells. Kwack, M.H., Choi, B.Y., Sung, Y.K. Mol. Cells (2006)
- Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma. Nakatsura, T., Nishimura, Y. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. (2005)
- Identification of glypican-3 as a novel tumor marker for melanoma. Nakatsura, T., Kageshita, T., Ito, S., Wakamatsu, K., Monji, M., Ikuta, Y., Senju, S., Ono, T., Nishimura, Y. Clin. Cancer Res. (2004)
- Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. Huber, R., Crisponi, L., Mazzarella, R., Chen, C.N., Su, Y., Shizuya, H., Chen, E.Y., Cao, A., Pilia, G. Genomics (1997)