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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus streptomyces (actinomycetales).

A novel meroterpenoid, azamerone, was isolated from the saline culture of a new marine-derived bacterium related to the genus Streptomyces. Azamerone is composed of an unprecedented chloropyranophthalazinone core with a 3-chloro-6-hydroxy-2,2,6-trimethylcyclohexylmethyl side chain. The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text][1]

References

  1. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus streptomyces (actinomycetales). Cho, J.Y., Kwon, H.C., Williams, P.G., Jensen, P.R., Fenical, W. Org. Lett. (2006) [Pubmed]
 
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