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Disease relevance of Actinomycetales


High impact information on Actinomycetales

  • Ketoconazole and the Actinomycetales [6].
  • Many species within the order Actinomycetales contain one or more soluble cytochrome P450 monooxygenases, often substrate-inducible and responsible for a variety of xenobiotic transformations [7].
  • Several members of the Actinomycetales, including the medically important mycobacteria, produce 1-D-myo-inosityl-2-(N-acetyl-L-cysteinyl)amino-2-deoxy-alpha-D- glucop yranoside (trivial name mycothiol) as their principal low-molecular-mass thiol [8].
  • Members of the Actinomycetales were very prevalent in microcosms with xylene and Cr(VI); gene copy numbers of biphenyl dioxygenase and phenol hydroxylase (but not other oxygenases) were elevated in these microcosms, as determined by real-time PCR [9].
  • To characterize the function of the Lon protease within the Actinomycetales, a viable M. smegmatis Deltalon strain was constructed, demonstrating that lon is not essential under certain conditions [10].

Chemical compound and disease context of Actinomycetales

  • Microbacterium species (formerly CDC [Centers for Disease Control and Prevention] coryneform group A-4 and A-5 bacteria) are widely distributed in the environment and rarely cause infections in humans [11].
  • Aerobic mineralization of vinyl chloride by a bacterium of the order Actinomycetales [12].
  • These strains had been initially identified as Centers for Disease Control and Prevention coryneform group B-1 and B-3 bacteria (whitishgrayish colonies of 2 mm or greater in diameter after 24 h of incubation, respiratory metabolism, absent or weak acid production from sugars, and hydrolysis of gelatin) [13].
  • These two strains along with a limited number of strains collected at the Special Bacterial Pathogens Laboratory (Division of Bacterial Diseases, Centers for Disease Control, Atlanta, Ga.) may represent a subgroup of coryneform group A-4 [14].
  • Studies on Actinomycetales producing antibiotics only on agar culture. II. Isolation, structure and biological properties of N-carbamoyl-D-glucosamine (substance SF-1993) [15].

Biological context of Actinomycetales


Anatomical context of Actinomycetales


Gene context of Actinomycetales


  1. Actinomycetales infection in the acquired immunodeficiency syndrome. Holtz, H.A., Lavery, D.P., Kapila, R. Ann. Intern. Med. (1985) [Pubmed]
  2. Heterogeneity within human-derived centers for disease control and prevention (CDC) coryneform group ANF-1-like bacteria and description of Corynebacterium auris sp. nov. Funke, G., Lawson, P.A., Collins, M.D. Int. J. Syst. Bacteriol. (1995) [Pubmed]
  3. Description of human-derived Centers for Disease Control coryneform group 2 bacteria as Actinomyces bernardiae sp. nov. Funke, G., Ramos, C.P., Fernández-Garayzábal, J.F., Weiss, N., Collins, M.D. Int. J. Syst. Bacteriol. (1995) [Pubmed]
  4. Distribution and phylogenetic analysis of family 19 chitinases in Actinobacteria. Kawase, T., Saito, A., Sato, T., Kanai, R., Fujii, T., Nikaidou, N., Miyashita, K., Watanabe, T. Appl. Environ. Microbiol. (2004) [Pubmed]
  5. Studies on Actinomycetales producing antibiotics only on agar culture. I. Screening, taxonomy and morphology-productivity relationship of Streptomyces halstedii, strain SF-1993. Shomura, T., Yoshida, J., Amano, S., Kojima, M., Inouye, S., Niida, T. J. Antibiot. (1979) [Pubmed]
  6. Ketoconazole and the Actinomycetales. Martin, M.V. Lancet (1982) [Pubmed]
  7. Occurrence and biological function of cytochrome P450 monooxygenases in the actinomycetes. O'Keefe, D.P., Harder, P.A. Mol. Microbiol. (1991) [Pubmed]
  8. Biosynthesis of mycothiol: elucidation of the sequence of steps in Mycobacterium smegmatis. Bornemann, C., Jardine, M.A., Spies, H.S., Steenkamp, D.J. Biochem. J. (1997) [Pubmed]
  9. Soil microbial community responses to additions of organic carbon substrates and heavy metals (Pb and Cr). Nakatsu, C.H., Carmosini, N., Baldwin, B., Beasley, F., Kourtev, P., Konopka, A. Appl. Environ. Microbiol. (2005) [Pubmed]
  10. Species variation in ATP-dependent protein degradation: protease profiles differ between mycobacteria and protease functions differ between Mycobacterium smegmatis and Escherichia coli. Knipfer, N., Seth, A., Roudiak, S.G., Shrader, T.E. Gene (1999) [Pubmed]
  11. Endophthalmitis due to Microbacterium species: case report and review of microbacterium infections. Funke, G., Haase, G., Schnitzler, N., Schrage, N., Reinert, R.R. Clin. Infect. Dis. (1997) [Pubmed]
  12. Aerobic mineralization of vinyl chloride by a bacterium of the order Actinomycetales. Phelps, T.J., Malachowsky, K., Schram, R.M., White, D.C. Appl. Environ. Microbiol. (1991) [Pubmed]
  13. Isolation of Arthrobacter spp. from clinical specimens and description of Arthrobacter cumminsii sp. nov. and Arthrobacter woluwensis sp. nov. Funke, G., Hutson, R.A., Bernard, K.A., Pfyffer, G.E., Wauters, G., Collins, M.D. J. Clin. Microbiol. (1996) [Pubmed]
  14. Two similar but atypical strains of coryneform group A-4 isolated from patients with endophthalmitis. Coudron, P.E., Harris, R.C., Vaughan, M.G., Dalton, H.P. J. Clin. Microbiol. (1985) [Pubmed]
  15. Studies on Actinomycetales producing antibiotics only on agar culture. II. Isolation, structure and biological properties of N-carbamoyl-D-glucosamine (substance SF-1993). Omoto, S., Shomura, T., Suzuki, H., Inouye, S. J. Antibiot. (1979) [Pubmed]
  16. Bogoriella caseilytica gen. nov., sp. nov., a new alkaliphilic actinomycete from a soda lake in Africa. Groth, I., Schumann, P., Rajney, F.A., Martin, K., Schuetze, B., Augsten, K. Int. J. Syst. Bacteriol. (1997) [Pubmed]
  17. Production and partial characterization of antibody to cord factor (trehalose 6,6'-dimycolate) in mice. Fujiwara, N., Oka, S., Ide, M., Kashima, K., Honda, T., Yano, I. Microbiol. Immunol. (1999) [Pubmed]
  18. Kitasatosporia, a new genus of the order Actinomycetales. Omura, S., Takahashi, Y., Iwai, Y., Tanaka, H. J. Antibiot. (1982) [Pubmed]
  19. Ornithinicoccus hortensis gen. nov., sp. nov., a soil actinomycete which contains L-ornithine. Groth, I., Schumann, P., Martin, K., Schuetze, B., Augsten, K., Kramer, I., Stackebrandt, E. Int. J. Syst. Bacteriol. (1999) [Pubmed]
  20. Genomic diversity and phylogenetic relationships among lipid-requiring diphtheroids from humans and characterization of Corynebacterium macginleyi sp. nov. Riegel, P., Ruimy, R., de Briel, D., Prévost, G., Jehl, F., Christen, R., Monteil, H. Int. J. Syst. Bacteriol. (1995) [Pubmed]
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