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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.[1]


  1. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Hatano, M., Roberts, C.W., Minden, M., Crist, W.M., Korsmeyer, S.J. Science (1991) [Pubmed]
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