- Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies. Shuman, C., Smith, A.C., Steele, L., Ray, P.N., Clericuzio, C., Zackai, E., Parisi, M.A., Meadows, A.T., Kelly, T., Tichauer, D., Squire, J.A., Sadowski, P., Weksberg, R. Am. J. Med. Genet. A (2006)