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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hepatoblastoma


High impact information on Hepatoblastoma


Chemical compound and disease context of Hepatoblastoma


Biological context of Hepatoblastoma


Anatomical context of Hepatoblastoma


Gene context of Hepatoblastoma

  • Messenger RNA (mRNA) analysis showed that CDKN2C is expressed in all hepatoblastoma samples studied, while both CDKN2A and CDKN2B genes are not transcribed in the cancer specimens as well as in the matched normal liver tissues [19].
  • These results show that CDKN2A gene family alterations are not involved in hepatoblastoma development, whereas changes in cyclin D types might play a role in this type of tumor [19].
  • p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19 [26].
  • Furthermore, SHBG alleles within the general population contain at least 6-10 TAAAA repeats, and the transcriptional activity of a human SHBG promoter-luciferase reporter construct containing 6 TAAAA repeats was significantly lower than for similar reporter constructs containing 7-10 TAAAA repeats when tested in human HepG2 hepatoblastoma cells [27].
  • Large variations were noticed for expression of the NQO2 and NQO1 genes among various tissues, 1336 bp of the 5'-flanking region of the NQO2 gene containing ARE and XRE was found sufficient to increase expression of the CAT gene in response to beta-naphthoflavone and tCDD in transfected human hepatoblastoma (Hep-G2) cells [28].
  • In vitro, PI3K inhibition diminished hepatoblastoma cell growth being accompanied by reduced AKT and GSK-3beta phosphorylation [29].

Analytical, diagnostic and therapeutic context of Hepatoblastoma


  1. HBV infection of cell culture: evidence for multivalent and cooperative attachment. Paran, N., Geiger, B., Shaul, Y. EMBO J. (2001) [Pubmed]
  2. Fetal- and tumor-specific regulation of growth hormone receptor messenger RNA expression in human liver. Zogopoulos, G., Albrecht, S., Pietsch, T., Alpert, L., von Schweinitz, D., Lefèbvre, Y., Goodyer, C.G. Cancer Res. (1996) [Pubmed]
  3. Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas. Waber, P.G., Chen, J., Nisen, P.D. Cancer Res. (1993) [Pubmed]
  4. Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam. Anna, C.H., Sills, R.C., Foley, J.F., Stockton, P.S., Ton, T.V., Devereux, T.R. Cancer Res. (2000) [Pubmed]
  5. Cell-specific regulation of human CYP1A1 and CYP1B1 genes. Kress, S., Greenlee, W.F. Cancer Res. (1997) [Pubmed]
  6. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion? Strand, S., Hofmann, W.J., Hug, H., Müller, M., Otto, G., Strand, D., Mariani, S.M., Stremmel, W., Krammer, P.H., Galle, P.R. Nat. Med. (1996) [Pubmed]
  7. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J.C., Staels, B., Auwerx, J. J. Clin. Invest. (1995) [Pubmed]
  8. Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma. Amuro, Y., Tanaka, M., Higashino, K., Hayashi, E., Endo, T., Kishimoto, S., Nakabayashi, H., Sato, J. J. Clin. Invest. (1982) [Pubmed]
  9. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Tan, X., Apte, U., Micsenyi, A., Kotsagrelos, E., Luo, J.H., Ranganathan, S., Monga, D.K., Bell, A., Michalopoulos, G.K., Monga, S.P. Gastroenterology (2005) [Pubmed]
  10. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Monga, S.P., Monga, H.K., Tan, X., Mulé, K., Pediaditakis, P., Michalopoulos, G.K. Gastroenterology (2003) [Pubmed]
  11. Fatty acid ethyl esters decrease human hepatoblastoma cell proliferation and protein synthesis. Szczepiorkowski, Z.M., Dickersin, G.R., Laposata, M. Gastroenterology (1995) [Pubmed]
  12. Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy. Mauzeroll, J., Bard, A.J., Owhadian, O., Monks, T.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  13. Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach--results of the first prospective study of the International Society of Pediatric Oncology. Pritchard, J., Brown, J., Shafford, E., Perilongo, G., Brock, P., Dicks-Mireaux, C., Keeling, J., Phillips, A., Vos, A., Plaschkes, J. J. Clin. Oncol. (2000) [Pubmed]
  14. Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study. Douglass, E.C., Reynolds, M., Finegold, M., Cantor, A.B., Glicksman, A. J. Clin. Oncol. (1993) [Pubmed]
  15. Promotion of N-nitrosodiethylamine-initiated hepatocellular tumors and hepatoblastomas by 2,3,7,8-tetrachlorodibenzo-p-dioxin or Aroclor 1254 in C57BL/6, DBA/2, and B6D2F1 mice. Beebe, L.E., Fornwald, L.W., Diwan, B.A., Anver, M.R., Anderson, L.M. Cancer Res. (1995) [Pubmed]
  16. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Venugopal, R., Jaiswal, A.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  17. Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells. Lee, Y.S., Kang, Y.S., Lee, S.H., Kim, J.A. Cell Death Differ. (2000) [Pubmed]
  18. Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase. Baldini, P.M., De Vito, P., Antenucci, D., Vismara, D., D'Aquilio, F., Luly, P., Zalfa, F., Bagni, C., Di Nardo, P. Cell Death Differ. (2004) [Pubmed]
  19. Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. Iolascon, A., Giordani, L., Moretti, A., Basso, G., Borriello, A., Della Ragione, F. Hepatology (1998) [Pubmed]
  20. Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression. Suzuki, A., Hayashida, M., Kawano, H., Sugimoto, K., Nakano, T., Shiraki, K. Hepatology (2000) [Pubmed]
  21. Regulation of erythropoietin production in a human hepatoblastoma cell line. Nielsen, O.J., Schuster, S.J., Kaufman, R., Erslev, A.J., Caro, J. Blood (1987) [Pubmed]
  22. Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor. Ikari, N., Yoshino, H., Moses, A.C., Flier, J.S. Mol. Endocrinol. (1988) [Pubmed]
  23. Immunoreactivity of sinusoids in hepatoblastoma: an immunohistochemical study using lectin UEA-1 and antibodies against endothelium-associated antigens, including CD34. Ruck, P., Xiao, J.C., Kaiserling, E. Histopathology (1995) [Pubmed]
  24. Malignant hepatic tumours in children: incidence, clinical features and aetiology. Mann, J.R., Kasthuri, N., Raafat, F., Pincott, J.R., Parkes, S.E., Muir, K.R., Ingram, L.C., Cameron, A.H. Paediatric and perinatal epidemiology. (1990) [Pubmed]
  25. Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha). Stier, H., Fahimi, H.D., Van Veldhoven, P.P., Mannaerts, G.P., Völkl, A., Baumgart, E. Differentiation (1998) [Pubmed]
  26. p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19. Hartmann, W., Waha, A., Koch, A., Goodyer, C.G., Albrecht, S., von Schweinitz, D., Pietsch, T. Am. J. Pathol. (2000) [Pubmed]
  27. Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence. Hogeveen, K.N., Talikka, M., Hammond, G.L. J. Biol. Chem. (2001) [Pubmed]
  28. Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression. Jaiswal, A.K. J. Biol. Chem. (1994) [Pubmed]
  29. Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. Hartmann, W., Küchler, J., Koch, A., Friedrichs, N., Waha, A., Endl, E., Czerwitzki, J., Metzger, D., Steiner, S., Wurst, P., Leuschner, I., von Schweinitz, D., Buettner, R., Pietsch, T. Clin. Cancer Res. (2009) [Pubmed]
  30. Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: a report from the Childrens Cancer Study Group. Ortega, J.A., Krailo, M.D., Haas, J.E., King, D.R., Ablin, A.R., Quinn, J.J., Feusner, J., Campbell, J.R., Lloyd, D.A., Cherlow, J. J. Clin. Oncol. (1991) [Pubmed]
  31. Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation. Dumortier, J., Bizollon, T., Chevallier, M., Ducerf, C., Baulieux, J., Scoazec, J.Y., Trepo, C. Gut (1999) [Pubmed]
  32. Results of simultaneous and sequential pediatric liver and kidney transplantation. Rogers, J., Bueno, J., Shapiro, R., Scantlebury, V., Mazariegos, G., Fung, J., Reyes, J. Transplantation (2001) [Pubmed]
  33. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. Jaiswal, A.K., Burnett, P., Adesnik, M., McBride, O.W. Biochemistry (1990) [Pubmed]
  34. The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Byrne, J.A., Smith, P.J. Hum. Genet. (1993) [Pubmed]
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