Glucose transporter expression in skeletal muscle of endurance-trained individuals.
Two recently identified glucose transporters, GLUT8 and GLUT12, are expressed in human skeletal muscle and may be involved in insulin-mediated sugar transport. PURPOSE: The purpose of this study was to measure GLUT8 and GLUT12 mRNA levels in endurance-trained versus sedentary individuals in an effort to determine the effect of repeated days of contractile activity on gene expression. METHODS: GLUT 4, 8, and 12 mRNA were measured in biopsies from the vastus lateralis using quantitative real-time PCR in endurance-trained (N=16, age=22.0+/-0.9 yr, VO(2 max) (L.min(-1))=4.13+/-0.25) and sedentary (N=15, age=21.3+/-0.8 yr, VO(2 max) (L.min(-1))=3.21+/-0.24) subjects. RESULTS: GLUT12 mRNA was lower (40+/-14%, P<0.05) in the exercise-trained compared with the sedentary subjects. There was no difference between groups in GLUT8 mRNA content. mRNA of the insulin-sensitive glucose transporter (GLUT4) was 78+/-27% (P<0.05) higher in skeletal muscle from endurance-trained compared with sedentary individuals. CONCLUSION: These findings suggest an isoform-specific effect on the mRNA of the glucose transporters in human skeletal muscle with repeated days of contractile activity.[1]References
- Glucose transporter expression in skeletal muscle of endurance-trained individuals. Seki, Y., Berggren, J.R., Houmard, J.A., Charron, M.J. Medicine and science in sports and exercise. (2006) [Pubmed]
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