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Gene Review

SLC2A12  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: GLUT-12, GLUT12, GLUT8, Glucose transporter type 12, Solute carrier family 2, facilitated glucose transporter member 12
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Disease relevance of SLC2A12


High impact information on SLC2A12

  • Some studies suggest a role for GLUT8 in the endoplasmic reticulum stress [6].
  • The discovery of the brain expression of the translocable glucose transporters, GLUT4 then GLUT8, led to the question of their putative role in the central nervous system, particularly in relation to insulin effect [6].
  • The glucose transporter GLUT8 cycles between intracellular vesicles and the plasma membrane [7].
  • Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex [7].
  • As a consequence, GLUT8 accumulates at the plasma membrane at comparable levels to those observed in K44A-transfected cells [7].

Chemical compound and disease context of SLC2A12


Biological context of SLC2A12

  • The mouse GLUT-12 gene, located on chromosome 10, comprises at least five exons and encodes a 622 amino acid protein exhibiting 83% sequence identity and 91% sequence similarity to human GLUT-12 [8].
  • Thus, our data demonstrate that recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and that endocytosis might be the main site at which GLUT8 is likely to be regulated [7].
  • Yeast two-hybrid analyses and GST pulldown assays reveal that the LL signal constitutes a binding site for the beta2-adaptin subunit of the heterotetrameric AP-2 adaptor complex, implicating this motif in targeting of GLUT8 to clathrin-coated vesicles [7].
  • PURPOSE: The purpose of this study was to measure GLUT8 and GLUT12 mRNA levels in endurance-trained versus sedentary individuals in an effort to determine the effect of repeated days of contractile activity on gene expression [9].
  • Primers were designed by using sequences that are not conserved in GLUT1 to GLUT5 and that contain the glycosylation region of GLUT8 [10].

Anatomical context of SLC2A12


Associations of SLC2A12 with chemical compounds

  • Identification of a novel glucose transporter-like protein-GLUT-12 [1].
  • The apical localization of GLUT12 in the distal tubules and collecting ducts suggests that it could contribute to additional glucose reabsorption in the late nephron [12].
  • Changing the glutamate to arginine as found in GLUT4 (RRXXXLL) alters GLUT8 endocytosis and retains the transporter at the PM [11].
  • In the current study, we have utilized the Xenopus laevis oocyte expression system to assay transport of the glucose analog 2-deoxy-D-glucose and characterize the glucose transport properties and hexose affinities of GLUT12 [13].
  • METHODS: Reverse transcription-polymerase chain reaction was performed on total RNA extracted from cultured prostate carcinoma cells LNCaP, C4, C4-2, and C4-2B using primers to amplify GLUT1, GLUT12, or the housekeeping gene, 36B4 [3].

Other interactions of SLC2A12

  • Immunofluorescent studies demonstrated that GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers [14].
  • Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1-GLUT12 and HMIT; gene name SLC2A) are now recognised [15].
  • Genomic organization of GLUT-12 is highly conserved with GLUT-10 but distinct from GLUTs 1-5 [1].
  • GLUT6 and GLUT8 appear to be regulated by sub-cellular redistribution, because they are targeted to intra-cellular compartments by dileucine motifs in a dynamin dependent manner [16].
  • The mRNA for three of these, the glucose transporters (GLUT) GLUT8, GLUT11 and GLUT12, have been detected in human skeletal muscle [4].

Analytical, diagnostic and therapeutic context of SLC2A12


  1. Identification of a novel glucose transporter-like protein-GLUT-12. Rogers, S., Macheda, M.L., Docherty, S.E., Carty, M.D., Henderson, M.A., Soeller, W.C., Gibbs, E.M., James, D.E., Best, J.D. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  2. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. Macheda, M.L., Rogers, S., Best, J.D. J. Cell. Physiol. (2005) [Pubmed]
  3. Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Chandler, J.D., Williams, E.D., Slavin, J.L., Best, J.D., Rogers, S. Cancer (2003) [Pubmed]
  4. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. Gaster, M., Handberg, A., Schürmann, A., Joost, H.G., Beck-Nielsen, H., Schrøder, H.D. Pflugers Arch. (2004) [Pubmed]
  5. Differential expression of GLUT12 in breast cancer and normal breast tissue. Rogers, S., Docherty, S.E., Slavin, J.L., Henderson, M.A., Best, J.D. Cancer Lett. (2003) [Pubmed]
  6. Translocable glucose transporters in the brain: where are we in 2006? Alquier, T., Leloup, C., Lorsignol, A., P??nicaud, L. Diabetes (2006) [Pubmed]
  7. Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex. Schmidt, U., Briese, S., Leicht, K., Schürmann, A., Joost, H.G., Al-Hasani, H. J. Cell. Sci. (2006) [Pubmed]
  8. Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Wood, I.S., Hunter, L., Trayhurn, P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  9. Glucose transporter expression in skeletal muscle of endurance-trained individuals. Seki, Y., Berggren, J.R., Houmard, J.A., Charron, M.J. Medicine and science in sports and exercise. (2006) [Pubmed]
  10. Expression and regulation of glucose transporter 8 in rat Leydig cells. Chen, Y., Nagpal, M.L., Lin, T. J. Endocrinol. (2003) [Pubmed]
  11. GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartment. Augustin, R., Riley, J., Moley, K.H. Traffic (2005) [Pubmed]
  12. Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Linden, K.C., DeHaan, C.L., Zhang, Y., Glowacka, S., Cox, A.J., Kelly, D.J., Rogers, S. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  13. Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes. Rogers, S., Chandler, J.D., Clarke, A.L., Petrou, S., Best, J.D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. Stuart, C.A., Yin, D., Howell, M.E., Dykes, R.J., Laffan, J.J., Ferrando, A.A. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  15. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Wood, I.S., Trayhurn, P. Br. J. Nutr. (2003) [Pubmed]
  16. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Joost, H.G., Thorens, B. Mol. Membr. Biol. (2001) [Pubmed]
  17. Expression of GLUT12 in the fetal membranes of the human placenta. Gude, N.M., Stevenson, J.L., Murthi, P., Rogers, S., Best, J.D., Kalionis, B., King, R.G. Placenta (2005) [Pubmed]
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