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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

HIV pathogenesis: Nef loses control.

In this issue of Cell, Schindler et al. (2006) show that the Nef protein from nonpathogenic strains of simian immunodeficiency virus ( SIV) induces the downregulation of host T cell receptor/CD3, whereas Nef from human immunodeficiency virus (HIV-1) does not. This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus.[1]


  1. HIV pathogenesis: Nef loses control. Foster, J.L., Garcia, J.V. Cell (2006) [Pubmed]
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