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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cell wall-mediated neuronal damage in early sepsis.

Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr(-/-) mice but was partially mitigated in mice lacking cell wall recognition proteins TLR2 and Nod2 and in mice overexpressing interleukin-10 (IL-10) in macrophages. Thus, cell wall drives SAND through IL-10-repressible inflammatory events. Treatment with CDP-choline ameliorated SAND, suggesting that it may be an effective adjunctive therapy to increase survival and reduce organ damage in sepsis.[1]

References

  1. Cell wall-mediated neuronal damage in early sepsis. Orihuela, C.J., Fillon, S., Smith-Sielicki, S.H., El Kasmi, K.C., Gao, G., Soulis, K., Patil, A., Murray, P.J., Tuomanen, E.I. Infect. Immun. (2006) [Pubmed]
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