Gene Review:
Il10 - interleukin 10
Mus musculus
Synonyms:
CSIF, Cytokine synthesis inhibitory factor, IL-10, Il-10, Interleukin-10, ...
- Role of toll-like receptors in spontaneous commensal-dependent colitis. Rakoff-Nahoum, S., Hao, L., Medzhitov, R. Immunity (2006)
- Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Ko, K.S., Lee, M., Koh, J.J., Kim, S.W. Mol. Ther. (2001)
- Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production. Pasche, B., Kalaydjiev, S., Franz, T.J., Kremmer, E., Gailus-Durner, V., Fuchs, H., Hrabé de Angelis, M., Lengeling, A., Busch, D.H. Infect. Immun. (2005)
- Interleukin 10 protects mice from lethal endotoxemia. Howard, M., Muchamuel, T., Andrade, S., Menon, S. J. Exp. Med. (1993)
- T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. Davidson, N.J., Leach, M.W., Fort, M.M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D.J., Rennick, D.M. J. Exp. Med. (1996)
- IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. Wilson, M.S., Elnekave, E., Mentink-Kane, M.M., Hodges, M.G., Pesce, J.T., Ramalingam, T.R., Thompson, R.W., Kamanaka, M., Flavell, R.A., Keane-Myers, A., Cheever, A.W., Wynn, T.A. J. Clin. Invest. (2007)
- T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice. Sasaki, H., Suzuki, N., Kent, R., Kawashima, N., Takeda, J., Stashenko, P. J. Immunol. (2008)
- Use of perphenazine to control cannibalism in DBA/1 mice. Carter, D.B., Kennett, M.J., Franklin, C.L. Comp. Med. (2002)
- Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice. Toth, L.A., Opp, M.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001)
- Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice. Harvey, D., Smith, R., English, K., Mahon, B., Commins, S. Physiol. Behav. (2006)
- Differential regulation of murine T lymphocyte subsets. Fitch, F.W., McKisic, M.D., Lancki, D.W., Gajewski, T.F. Annu. Rev. Immunol. (1993)
- Interleukin-10-deficient mice develop chronic enterocolitis. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., Müller, W. Cell (1993)
- Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Mathur, R.K., Awasthi, A., Wadhone, P., Ramanamurthy, B., Saha, B. Nat. Med. (2004)
- Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice. Abe, T., Arai, T., Ogawa, A., Hiromatsu, T., Masuda, A., Matsuguchi, T., Nimura, Y., Yoshikai, Y. Hepatology (2004)
- Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Louis, H., Van Laethem, J.L., Wu, W., Quertinmont, E., Degraef, C., Van den Berg, K., Demols, A., Goldman, M., Le Moine, O., Geerts, A., Devière, J. Hepatology (1998)
- Substance P regulates Th1-type colitis in IL-10 knockout mice. Weinstock, J.V., Blum, A., Metwali, A., Elliott, D., Bunnett, N., Arsenescu, R. J. Immunol. (2003)
- Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Elliott, D.E., Setiawan, T., Metwali, A., Blum, A., Urban, J.F., Weinstock, J.V. Eur. J. Immunol. (2004)
- The peroxisome proliferator-activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency. Lytle, C., Tod, T.J., Vo, K.T., Lee, J.W., Atkinson, R.D., Straus, D.S. Inflamm. Bowel Dis. (2005)
- The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Kosarová, M., Havelková, H., Krulová, M., Demant, P., Lipoldová, M. Immunogenetics. (1999)
- Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Mähler, M., Most, C., Schmidtke, S., Sundberg, J.P., Li, R., Hedrich, H.J., Churchill, G.A. Genomics (2002)
- Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. de Ledesma, A.M., Desai, A.N., Bolivar, V.J., Symula, D.J., Flaherty, L. Mamm. Genome (2006)
- Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. Go, N.F., Castle, B.E., Barrett, R., Kastelein, R., Dang, W., Mosmann, T.R., Moore, K.W., Howard, M. J. Exp. Med. (1990)
- Altered immune responses in interleukin 10 transgenic mice. Hagenbaugh, A., Sharma, S., Dubinett, S.M., Wei, S.H., Aranda, R., Cheroutre, H., Fowell, D.J., Binder, S., Tsao, B., Locksley, R.M., Moore, K.W., Kronenberg, M. J. Exp. Med. (1997)
- Interleukin-10 determines viral clearance or persistence in vivo. Brooks, D.G., Trifilo, M.J., Edelmann, K.H., Teyton, L., McGavern, D.B., Oldstone, M.B. Nat. Med. (2006)
- Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Lumeng, C.N., Bodzin, J.L., Saltiel, A.R. J. Clin. Invest. (2007)
- Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells. Erard, F., Wild, M.T., Garcia-Sanz, J.A., Le Gros, G. Science (1993)
- Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Silva, J.S., Morrissey, P.J., Grabstein, K.H., Mohler, K.M., Anderson, D., Reed, S.G. J. Exp. Med. (1992)
- Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Lee, T.S., Chau, L.Y. Nat. Med. (2002)
- IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. O'Farrell, A.M., Liu, Y., Moore, K.W., Mui, A.L. EMBO J. (1998)
- Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. Murakami, M., Penrose, J.F., Urade, Y., Austen, K.F., Arm, J.P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Bhattacharyya, S., Sen, P., Wallet, M., Long, B., Baldwin, A.S., Tisch, R. Blood (2004)
- IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. Marra, L.E., Zhang, Z.X., Joe, B., Campbell, J., Levy, G.A., Penninger, J., Zhang, L. J. Immunol. (2004)
- Direct interaction of C/EBPdelta and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage. Chiang, B.T., Liu, Y.W., Chen, B.K., Wang, J.M., Chang, W.C. J. Biomed. Sci. (2006)
- Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice. Hansson, A.S., Johansson, A.C., Holmdahl, R. Arthritis Res. Ther. (2004)
- Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells. Lu-Kuo, J.M., Austen, K.F., Katz, H.R. J. Biol. Chem. (1996)
- The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages. Riemann, M., Endres, R., Liptay, S., Pfeffer, K., Schmid, R.M. J. Immunol. (2005)
- Role of interleukin-4 (IL-4) and IL-10 in serum immunoglobulin G antibody responses following mucosal or systemic reovirus infection. Mathers, A.R., Cuff, C.F. J. Virol. (2004)
- Regulation of the mRNA expression for tumor necrosis factor-alpha in rat liver macrophages. Grewe, M., Gausling, R., Gyufko, K., Hoffmann, R., Decker, K. J. Hepatol. (1994)
- Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Stämpfli, M.R., Cwiartka, M., Gajewska, B.U., Alvarez, D., Ritz, S.A., Inman, M.D., Xing, Z., Jordana, M. Am. J. Respir. Cell Mol. Biol. (1999)
- Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. Tarrant, T.K., Silver, P.B., Wahlsten, J.L., Rizzo, L.V., Chan, C.C., Wiggert, B., Caspi, R.R. J. Exp. Med. (1999)
- Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. Fiorentino, D.F., Bond, M.W., Mosmann, T.R. J. Exp. Med. (1989)
- Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Azuma, Y., Kanai, C., Moriizumi, E., Nomura, T., Nakamura, T., Sakaguchi, S. J. Clin. Invest. (2004)
- Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. Räisänen-Sokolowski, A., Mottram, P.L., Glysing-Jensen, T., Satoskar, A., Russell, M.E. J. Clin. Invest. (1997)
- Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. Kasama, T., Strieter, R.M., Lukacs, N.W., Lincoln, P.M., Burdick, M.D., Kunkel, S.L. J. Clin. Invest. (1995)
- Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer. Kundu, N., Beaty, T.L., Jackson, M.J., Fulton, A.M. J. Natl. Cancer Inst. (1996)