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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Properties of acidic saccharides produced by B16 melanoma cells treated with 1-methyl-3-isobutylxanthine.

A cyclic nucleotide phosphodiesterase inhibitor, 1-methyl-3-isobutylxanthine, promoted the differentiation and maturation of B16 melanoma cells, phenomena associated with biological alterations in the surface properties of the cells. 1-Methyl-3-isobutylxanthien inhibited cell replication and increased the intracellular content of melanin and cyclic adenosine 3':5'-monophosphate. Significantly greater amounts of sialoglycoproteins were associated with 1-methyl-3-isobutylxanthine-treated cells. However, the total amount of [3H] glucosamine incorporated into anionic polysaccharide (both sialoglycopeptide and mucopolysaccharides) was not significantly changed.[1]

References

  1. Properties of acidic saccharides produced by B16 melanoma cells treated with 1-methyl-3-isobutylxanthine. Banks, J., Kreider, J.W., Sato, C., Davidson, E.A. Cancer Res. (1975) [Pubmed]
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