The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cnp  -  2',3'-cyclic nucleotide 3' phosphodiesterase

Mus musculus

Synonyms: 2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPase, Cnp-1, Cnp1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cnp1


High impact information on Cnp1


Chemical compound and disease context of Cnp1


Biological context of Cnp1


Anatomical context of Cnp1


Associations of Cnp1 with chemical compounds


Regulatory relationships of Cnp1


Other interactions of Cnp1

  • In controls, the CNPase and MBP were localized exclusively in white matter in the CNS [20].
  • No abnormal accumulation of MAG, MBP, or CNP in the cell body was found [31].
  • These changes are characterized by mislocalized Caspr immunostaining, combined with a decrease of clustered Na+ channels, and occur before axonal degeneration and microglial invasion, both prominent in older Cnp1-null mice [19].
  • Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes [32].
  • Furthermore, significant reductions of CNPase and 120 kD NCAM were also present at 2 months, indicating that the oligodendroglial abnormalities begin at a relatively early age [33].

Analytical, diagnostic and therapeutic context of Cnp1


  1. In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice. Godfraind, C., Friedrich, V.L., Holmes, K.V., Dubois-Dalcq, M. J. Cell Biol. (1989) [Pubmed]
  2. Generation of a monoclonal antibody against the myelin protein CNP (2',3'-cyclic nucleotide 3'-phosphodiesterase) suitable for biochemical and for immunohistochemical investigations of CNP. Reiser, G., Kunzelmann, U., Steinhilber, G., Binmöller, F.J. Neurochem. Res. (1994) [Pubmed]
  3. Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. Bernier, L., Alvarez, F., Norgard, E.M., Raible, D.W., Mentaberry, A., Schembri, J.G., Sabatini, D.D., Colman, D.R. J. Neurosci. (1987) [Pubmed]
  4. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. Masciarelli, S., Horner, K., Liu, C., Park, S.H., Hinckley, M., Hockman, S., Nedachi, T., Jin, C., Conti, M., Manganiello, V. J. Clin. Invest. (2004) [Pubmed]
  5. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. Robichaud, A., Stamatiou, P.B., Jin, S.L., Lachance, N., MacDonald, D., Laliberté, F., Liu, S., Huang, Z., Conti, M., Chan, C.C. J. Clin. Invest. (2002) [Pubmed]
  6. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P.E., Griffiths, I.R., Nave, K.A. Nat. Genet. (2003) [Pubmed]
  7. Increased cyclic nucleotide phosphodiesterase activity in leukaemic lymphocytes. Hait, W.N., Weiss, B. Nature (1976) [Pubmed]
  8. Maturation and differentiation of B16 melanoma cells induced by theophylline treatment. Kreider, J.W., Wade, D.R., Rosenthal, M., Densley, T. J. Natl. Cancer Inst. (1975) [Pubmed]
  9. Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. Haga, T., Ross, E.M., Anderson, H.J., Gilman, A.G. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  10. Properties of acidic saccharides produced by B16 melanoma cells treated with 1-methyl-3-isobutylxanthine. Banks, J., Kreider, J.W., Sato, C., Davidson, E.A. Cancer Res. (1975) [Pubmed]
  11. Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture. La Rosa, F.G., Kumar, S., Prasad, K.N. J. Neurochem. (1996) [Pubmed]
  12. Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro. Lerner, U., Ransjö, M., Fredholm, B.B. Biochem. Pharmacol. (1986) [Pubmed]
  13. Evidence on hypomyelination of central nervous system in murine muscular dystrophy. Tsuji, S., Matsushita, H. J. Neurol. Sci. (1985) [Pubmed]
  14. Chromosomal locations of genes encoding 2',3' cyclic nucleotide 3'-phosphodiesterase and glial fibrillary acidic protein in the mouse. Bernier, L., Colman, D.R., D'Eustachio, P. J. Neurosci. Res. (1988) [Pubmed]
  15. Folding and function of the myelin proteins from primary sequence data. Inouye, H., Kirschner, D.A. J. Neurosci. Res. (1991) [Pubmed]
  16. Overexpression of 2',3'-cyclic nucleotide 3'-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination. Gravel, M., Peterson, J., Yong, V.W., Kottis, V., Trapp, B., Braun, P.E. Mol. Cell. Neurosci. (1996) [Pubmed]
  17. Alternative splicing of mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA. Kurihara, T., Monoh, K., Sakimura, K., Takahashi, Y. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  18. Isolation, cloning and characterization of a putative type-1 astrocyte cell line. Seidman, K.J., Teng, A.L., Rosenkopf, R., Spilotro, P., Weyhenmeyer, J.A. Brain Res. (1997) [Pubmed]
  19. CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS. Rasband, M.N., Tayler, J., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K.A., Bansal, R. Glia (2005) [Pubmed]
  20. Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse. Mikoshiba, K., Kohsaka, S., Hayakawa, T., Takamatsu, K., Tsukada, Y. J. Neurochem. (1985) [Pubmed]
  21. In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP. Peyron, F., Timsit, S., Thomas, J.L., Kagawa, T., Ikenaka, K., Zalc, B. J. Neurosci. Res. (1997) [Pubmed]
  22. Myelin basic protein deficit in the PNS of mld mutant mice recovers during development. Ginalski-Winkelmann, H., Omlin, F.X., Matthieu, J.M. Dev. Neurosci. (1983) [Pubmed]
  23. Identification of essential residues in 2',3'-cyclic nucleotide 3'-phosphodiesterase. Chemical modification and site-directed mutagenesis to investigate the role of cysteine and histidine residues in enzymatic activity. Lee, J., Gravel, M., Gao, E., O'Neill, R.C., Braun, P.E. J. Biol. Chem. (2001) [Pubmed]
  24. Comparative biochemical, morphological, and immunocytochemical studies between C-6 glial cells of early and late passages and advanced passages of glial cells derived from aged mouse cerebral hemispheres. Lee, K., Kentroti, S., Billie, H., Bruce, C., Vernadakis, A. Glia (1992) [Pubmed]
  25. Protein and lipid composition of radial component-enriched CNS myelin. Karthigasan, J., Kosaras, B., Nguyen, J., Kirschner, D.A. J. Neurochem. (1994) [Pubmed]
  26. Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene. Dyer, C.A., Phillbotte, T., Wolf, M.K., Billings-Gagliardi, S. Dev. Neurosci. (1997) [Pubmed]
  27. Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. Belachew, S., Chittajallu, R., Aguirre, A.A., Yuan, X., Kirby, M., Anderson, S., Gallo, V. J. Cell Biol. (2003) [Pubmed]
  28. Meiotic resumption in response to luteinizing hormone is independent of a G(i) family G protein or calcium in the mouse oocyte. Mehlmann, L.M., Kalinowski, R.R., Ross, L.F., Parlow, A.F., Hewlett, E.L., Jaffe, L.A. Dev. Biol. (2006) [Pubmed]
  29. Differential effects of activators of cAMP-dependent protein kinase and protein kinase C on cleavage of one-cell mouse embryos and protein synthesis and phosphorylation in one- and two-cell embryos. Poueymirou, W.T., Schultz, R.M. Dev. Biol. (1987) [Pubmed]
  30. Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. Vasta, V., Sonnenburg, W.K., Yan, C., Soderling, S.H., Shimizu-Albergine, M., Beavo, J.A. Biol. Reprod. (2005) [Pubmed]
  31. His36Pro point-mutated proteolipid protein retained in the endoplasmic reticulum of oligodendrocytes in the shaking pup. Song, J., Goetz, B.D., Duncan, I.D. Glia (2006) [Pubmed]
  32. Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes. Liu, H., Tang, J.R., Choi, Y.H., Napolitano, M., Hockman, S., Taira, M., Degerman, E., Manganiello, V.C. J. Biol. Chem. (2006) [Pubmed]
  33. Oligodendrocytes in aging mice lacking myelin-associated glycoprotein are dystrophic but not apoptotic. Weiss, M.D., Hammer, J., Quarles, R.H. J. Neurosci. Res. (2000) [Pubmed]
  34. Type II glucocorticoid receptors are expressed in oligodendrocytes and astrocytes. Vielkind, U., Walencewicz, A., Levine, J.M., Bohn, M.C. J. Neurosci. Res. (1990) [Pubmed]
  35. Immunocytochemical localization by electron microscopy of 2'3'-cyclic nucleotide 3'-phosphodiesterase in developing oligodendrocytes of normal and mutant brain. Braun, P.E., Sandillon, F., Edwards, A., Matthieu, J.M., Privat, A. J. Neurosci. (1988) [Pubmed]
  36. CNP2 mRNA directs synthesis of both CNP1 and CNP2 polypeptides. O'Neill, R.C., Minuk, J., Cox, M.E., Braun, P.E., Gravel, M. J. Neurosci. Res. (1997) [Pubmed]
  37. Developmental expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA in brains of normal and quaking mice. Kurihara, T., Takahashi, Y., Fujita, N., Sato, S., Miyatake, T. Brain Res. Mol. Brain Res. (1989) [Pubmed]
  38. Monoclonal antibody production to human and bovine 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNPase): high-specificity recognition in whole brain acetone powders and conservation of sequence between CNP1 and CNP2. Sprinkle, T.J., Agee, J.F., Tippins, R.B., Chamberlain, C.R., Faguet, G.B., De Vries, G.H. Brain Res. (1987) [Pubmed]
WikiGenes - Universities