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Vodicka, P. et al.

Vodicka, Stetina, Smerak, Vodickova, Naccarati, Barta, Hemminki,

Micronuclei, DNA single-strand breaks and DNA-repair activity in mice exposed to 1,3-butadiene by inhalation.

We investigated single-strand breaks and endonuclease III-sensitive sites in DNA along with gamma-irradiation-specific DNA-repair activity in hepatocytes and frequencies of micronuclei in polychromatic bone-marrow erythrocytes of male NMRI mice (2 months old, weight 30-35g) during sub-acute inhalation exposure to 1,3-butadiene (28 days, 500mg/m(3)) and up to 28 days after the exposure. Concentrations of 1,3-butadiene in blood, an indicator of internal exposure, moderately increased during the exposure period. The most interesting finding was that gamma-irradiation-specific DNA-repair activity gradually increased during exposure, being significantly higher compared with control levels on days 7 and 28 of exposure (P=0.005 and 0.035, respectively), reaching a maximum on day 1 after the termination of exposure (P=0.003) and then returning to control levels. A significant correlation between gamma-irradiation-specific DNA-repair activity and the concentration of 1,3-butadiene in blood (R=0.866, P=0.050) supports a possible induction of DNA-repair activity by the exposure to 1,3-butadiene and formation of its metabolites. The initial increase in micronucleus frequency ( micronuclei per 1000 cells) in the exposed mice continuously decreased from 20.4+/-5.1 (day 3) to 15.1+/-3.2 (day 28) within the exposure period, and subsequently from 12.4+/-5.1 to 4.6+/-1.6 in the period following termination of the 1,3-butadiene exposure, while micronucleus frequencies in control animals were significantly lower (from 1.7+/-1.5 to 4.2+/-0.8).[1]

References

Micronuclei, DNA single-strand breaks and DNA-repair activity in mice exposed to 1,3-butadiene by inhalation. Vodicka, P., Stetina, R., Smerak, P., Vodickova, L., Naccarati, A., Barta, I., Hemminki, K. Mutat. Res. (2006) [Pubmed]

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