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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells.

Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe(-/-)) mice were implanted into the cerebral ventricles of Apoe(-/-) mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.[1]

References

  1. Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells. Peister, A., Zeitouni, S., Pfankuch, T., Reger, R.L., Prockop, D.J., Raber, J. Exp. Neurol. (2006) [Pubmed]
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