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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms.

The nuclear transcription factors kappaB (NF-kappaB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-kappaB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-kappaB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-kappaB in brain dysfunctions arises from the identification of diverse NF-kappaB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-kappaB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.[1]

References

  1. Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms. Pizzi, M., Spano, P. Eur. J. Pharmacol. (2006) [Pubmed]
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