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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Plasma protein binding of sulphadiazine, sulphamethoxazole and trimethoprim determined by ultrafiltration.

The plasma protein binding of trimethoprim, sulphadiazine and sulphamethoxazole was studied at 37 degrees C by ultrafiltration. Plasma samples contained steady state levels of the drugs from ten volunteers from a cross-over comparative pharmacokinetic study on co-trimazine and co-trimoxazole. The three compounds were determined in plasma and ultrafiltrate by HPLC, the recoveries being close to 100% in each case. Freezing of spiked samples had no influence on the binding. Trimethoprim was 48.5-52.2% bound (mean 50.0%); sulphadiazine was 50.9-60.6% bound (mean 56.2%); and sulphamethoxazole was 74.3-80.8% bound (mean 76.9%). The significantly lower protein binding of sulphadiazine compared to sulphamethoxazole means that equivalent non-protein bound plasma levels of the two sulphonamides are achieved from smaller doses of co-trimazine than co-trimoxazole. Use of co-trimazine may thus minimize the risk of adverse reactions.[1]

References

  1. Plasma protein binding of sulphadiazine, sulphamethoxazole and trimethoprim determined by ultrafiltration. Wijkström, A., Westerlund, D. Journal of pharmaceutical and biomedical analysis. (1983) [Pubmed]
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