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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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NMR metabolic profiling of Aspergillus nidulans to monitor drug and protein activity.

We describe a general protocol for using comparative NMR metabolomics data to infer in vivo efficacy, specificity and toxicity of chemical leads within a drug discovery program. The methodology is demonstrated using Aspergillus nidulans to monitor the activity of urate oxidase and orotidine-5'-phosphate decarboxylase and the impact of 8-azaxanthine, an inhibitor of urate oxidase. 8-azaxanthine is shown to inhibit A. nidulans hyphal growth by in vivo inactivation of urate oxidase.[1]

References

  1. NMR metabolic profiling of Aspergillus nidulans to monitor drug and protein activity. Forgue, P., Halouska, S., Werth, M., Xu, K., Harris, S., Powers, R. J. Proteome Res. (2006) [Pubmed]
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