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Chemical Compound Review:

Xanthazol 3,5,7,8,9- pentazabicyclo[4.3.0]nona- 5,9...

Synonyms: Azaxanthine, NSC-756, NSC756, CHEMBL219341, SureCN308420, ...

Jung, D.K. et al., Saxena, A.K. et al., Forgue, P. et al., Colloc'h, N. et al., Davies, R.J.

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High impact information on Xanthazol

The crystal structures of PucM at 2.0 A and its complexes with the substrate analogs 8-azaxanthine and 5,6-diaminouracil reveal that even with their overall structure similarity, homotetrameric PucM and TTR are completely different, both in their electrostatic potential and in the size of the active sites located at the dimeric interface [1].
The structure of the active site of urate oxidase around the 8-azaxanthine inhibitor reveals an original mechanism of oxidation that does not require any ions or prosthetic groups [2].
Poly(A) forms a complex, tentatively assigned 1:1 stoichiometry, with 8-azaxanthine at pH 6, but no complexing occurs at pH 7 [3].
The methodology is demonstrated using Aspergillus nidulans to monitor the activity of urate oxidase and orotidine-5'-phosphate decarboxylase and the impact of 8-azaxanthine, an inhibitor of urate oxidase [4].
Inhibitors of guanine deaminase are important because it is reasonable to postulate that it will inhibit the conversion of 8-azaguanine to 8-azaxanthine and these could be used with advantage along with thioguanine and 8-azaguanine [5].

References

Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Jung, D.K., Lee, Y., Park, S.G., Park, B.C., Kim, G.H., Rhee, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 A resolution. Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prangé, T., Castro, B., Mornon, J.P. Nat. Struct. Biol. (1997) [Pubmed]
Complexes of poly(adenylic acid) with complementary monomers. Davies, R.J. Eur. J. Biochem. (1976) [Pubmed]
NMR metabolic profiling of Aspergillus nidulans to monitor drug and protein activity. Forgue, P., Halouska, S., Werth, M., Xu, K., Harris, S., Powers, R. J. Proteome Res. (2006) [Pubmed]
New imidazolylthiocarbamides as guanine deaminase inhibitors. Saxena, A.K., Ahmad, S., Shanker, K., Bhargava, K.P., Kishor, K. Die Pharmazie. (1980) [Pubmed]

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