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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBF{beta} dosage.

The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone development, megakaryocytes, granulocytes, and T cells. T-cell development was very sensitive to an incremental reduction of CBFbeta levels: mature thymocytes were decreased in number upon a 3-fold reduction in CBFbeta levels, and were virtually absent when CBFbeta levels were 6-fold lower. Partially penetrant consecutive differentiation blocks were found among early T-lineage progenitors within the CD4(-)CD8(-) double-negative 1 and downstream double-negative 2 thymocyte subsets. Our data define a critical CBFbeta threshold for normal T-cell development, and situate an essential role for core-binding factors during the earliest stages of T-cell development.[1]

References

  1. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBF{beta} dosage. Talebian, L., Li, Z., Guo, Y., Gaudet, J., Speck, M.E., Sugiyama, D., Kaur, P., Pear, W.S., Maillard, I., Speck, N.A. Blood (2007) [Pubmed]
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