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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rad52 and Rad59 exhibit both overlapping and distinct functions.

Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad59 have both overlapping as well as separate functions in DSB repair. Importantly, the N-terminus of Rad52 possesses functions not supplied by Rad59, which may account for its central role in homologous recombination.[1]


  1. Rad52 and Rad59 exhibit both overlapping and distinct functions. Feng, Q., D??ring, L., de Mayolo, A.A., Lettier, G., Lisby, M., Erdeniz, N., Mortensen, U.H., Rothstein, R. DNA Repair (Amst.) (2007) [Pubmed]
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