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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

In Vitro Antiviral Activity of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose against Hepatitis B Virus.

This study examined the antiviral activity of the root of Paeonia lactiflora PALL. Among the solvent fractions of the crude drug, the ethyl acetate fraction showed anti-hepatitis B virus (HBV) activity (IC(50), 8.1 mug/ml) in an HBV-producing HepG2.2.15 cell culture system. The active anti-HBV principle was isolated and identified as 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the crude drug by activity-guided fractionation. PGG isolated from P. lactiflora was examined for the inhibition of HBV multiplication by measurement of HBV DNA and hepatitis B surface antigen (HBsAg) levels in the extracellular medium of HepG2.2.15 cells after 8-d treatment. PGG decreased the level of extracellular HBV (IC(50), 1.0 mug/ml) in a dose-dependent manner. PGG also reduced the HBsAg level by 25% at a concentration of 4 mug/ml. The gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity. These results suggest that PGG could be a candidate for developing an anti-HBV agent.[1]

References

  1. In Vitro Antiviral Activity of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose against Hepatitis B Virus. Lee, S.J., Lee, H.K., Jung, M.K., Mar, W. Biol. Pharm. Bull. (2006) [Pubmed]
 
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