The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Paeonia

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Paeonia

  • After removal of polyphenolic compounds, the methanol extract of Paeonia suffruticosa still exerted potent inhibition of HIV-1 integrase (EC50 = 15 microg/ml) and the aqueous extract of Prunella vulgaris caused moderate inhibition (EC50 = 45 microg/ml) [1].
 

High impact information on Paeonia

  • Phylogenies of Adh1 and Adh2 genes suggest that a widespread Mediterranean peony, Paeonia officinalis, is a homoploid hybrid species between two allotetraploid species, Paeonia peregrina and a member of the Paeonia arietina species group [2].
  • Paraphyly of section Paeonia in the Adh2 gene tree may be caused by longer coalescence times and random sorting of ancestral alleles [3].
  • Inhibition of Na+,K(+)-ATPase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, a major constituent of both moutan cortex and Paeoniae radix [4].
  • Isolation and purification of four flavonoid constituents from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography [5].
  • Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full (1)H- and (13)C-NMR data for these natural products [6].
 

Biological context of Paeonia

 

Anatomical context of Paeonia

 

Associations of Paeonia with chemical compounds

  • Contents of peony constituents in an ethanol-water extract of Paeonia lactiflora Pall. sample could easily be determined by this method [16].
  • Phylogenetic utility of the glycerol-3-phosphate acyltransferase gene: evolution and implications in Paeonia (Paeoniaceae) [17].
  • A high-performance liquid chromatographic method for the determination of cinnamic acid in Cinnamomi ramulus and paeoniflorin in Paeoniae radix was established [18].
  • Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid [19].
  • The active constituents of Paeonia root bark were identified as paeonol and benzoic acid by spectroscopic analyses [20].
 

Gene context of Paeonia

  • From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1 [21].
  • The object of the study was to investigate the effect of Paeoniae Radix on the release of the chemokines such as MCP-1 and MCP-3 [15].
  • Atractylodis Lanceae Rhizoma, Cnidii Rhizoma, Angelicae Radix, Paeoniae Radix and Alismatis Rhizoma, which are crude ingredients of Toki-shakuyaku-san, significantly (p < 0.01) enhanced the secretion of CINC/gro at concentrations of 100 micrograms/ml [22].
  • In this study we investigated the phylogenetic utility of the GPAT gene at the interspecific level using the genus Paeonia (Paeoniaceae) as an example [17].
  • The method was also applicable to other preparations that contain Cinnamomi ramulus and Paeoniae radix such as Guey Chi Chia Long Ku Muu Li Tong, Kuei Chi Chien Chung Tong and Tang Kuei Chien Chung Tong [18].

References

  1. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. Au, T.K., Lam, T.L., Ng, T.B., Fong, W.P., Wan, D.C. Life Sci. (2001) [Pubmed]
  2. Speciation through homoploid hybridization between allotetraploids in peonies (Paeonia). Ferguson, D., Sang, T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Evolution of alcohol dehydrogenase genes in peonies (Paeonia): phylogenetic relationships of putative nonhybrid species. Sang, T., Donoghue, M.J., Zhang, D. Mol. Biol. Evol. (1997) [Pubmed]
  4. Inhibition of Na+,K(+)-ATPase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, a major constituent of both moutan cortex and Paeoniae radix. Satoh, K., Nagai, F., Ushiyama, K., Yasuda, I., Seto, T., Kano, I. Biochem. Pharmacol. (1997) [Pubmed]
  5. Isolation and purification of four flavonoid constituents from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography. Wang, X., Cheng, C., Sun, Q., Li, F., Liu, J., Zheng, C. Journal of chromatography. A. (2005) [Pubmed]
  6. Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia. Stavri, M., Mathew, K.T., Bucar, F., Gibbons, S. Planta Med. (2003) [Pubmed]
  7. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. Chen, L.C., Chou, M.H., Lin, M.F., Yang, L.L. Journal of clinical pharmacy and therapeutics. (2001) [Pubmed]
  8. Induction of apoptosis in HL-60 cells treated with medicinal herbs. Nishida, S., Kikuichi, S., Yoshioka, S., Tsubaki, M., Fujii, Y., Matsuda, H., Kubo, M., Irimajiri, K. Am. J. Chin. Med. (2003) [Pubmed]
  9. Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Takeuchi, T., Nishii, O., Okamura, T., Yaginuma, T. Am. J. Chin. Med. (1991) [Pubmed]
  10. Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB. Oh, G.S., Pae, H.O., Choi, B.M., Lee, H.S., Kim, I.K., Yun, Y.G., Kim, J.D., Chung, H.T. Int. Immunopharmacol. (2004) [Pubmed]
  11. Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Goto, H., Shimada, Y., Akechi, Y., Kohta, K., Hattori, M., Terasawa, K. Planta Med. (1996) [Pubmed]
  12. Stimulatory effect of paeoniflorin on the release of noradrenaline from ileal synaptosomes of guinea-pig in-vitro. Liu, T.P., Liu, M., Tsai, C.C., Lai, T.Y., Hsu, F.L., Cheng, J.T. J. Pharm. Pharmacol. (2002) [Pubmed]
  13. Stimulatory effect of the herbal medicine Keishi-bukuryo-gan on a cytokine-induced neutrophil chemoattractant, in rat ovarian cell culture. Yasui, T., Matsuzaki, T., Ushigoe, K., Kuwahara, A., Maegawa, M., Furumoto, H., Aono, T., Irahara, M. Am. J. Reprod. Immunol. (2003) [Pubmed]
  14. Effect of extract prepared from the roots of Paeonia lactiflora on endothelium-dependent relaxation and antioxidant enzyme activity in rats administered high-fat diet. Goto, H., Shimada, Y., Tanaka, N., Tanigawa, K., Itoh, T., Terasawa, K. Phytotherapy research : PTR. (1999) [Pubmed]
  15. Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Leem, K., Kim, H., Boo, Y., Lee, H.S., Kim, J.S., Yoo, Y.C., Ahn, H.J., Park, H.J., Seo, J.C., Kim, H.K., Jin, S.Y., Park, H.K., Chung, J.H., Cho, J.J. Phytotherapy research : PTR. (2004) [Pubmed]
  16. Capillary electrophoretic determination of the constituents of paeoniae radix. Wu, H.K., Sheu, S.J. Journal of chromatography. A. (1996) [Pubmed]
  17. Phylogenetic utility of the glycerol-3-phosphate acyltransferase gene: evolution and implications in Paeonia (Paeoniaceae). Tank, D.C., Sang, T. Mol. Phylogenet. Evol. (2001) [Pubmed]
  18. Determination of cinnamic acid and paeoniflorin in traditional Chinese medicinal preparations by high-performance liquid chromatography. Wen, K.C., Huang, C.Y., Liu, F.S. J. Chromatogr. (1992) [Pubmed]
  19. Aggregation inhibitory activity of minor acetophenones from Paeonia species. Lin, H.C., Ding, H.Y., Ko, F.N., Teng, C.M., Wu, Y.C. Planta Med. (1999) [Pubmed]
  20. Acaricidal activity of Paeonia suffruticosa root bark-derived compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Kim, H.K., Tak, J.H., Ahn, Y.J. J. Agric. Food Chem. (2004) [Pubmed]
  21. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor. Lee, S.J., Lee, H.M., Ji, S.T., Lee, S.R., Mar, W., Gho, Y.S. Cancer Lett. (2004) [Pubmed]
  22. Evidence that Toki-shakuyaku-san and its ingredients enhance the secretion of a cytokine-induced neutrophil chemoattractant (CINC/gro) in the ovulatory process. Irahara, M., Yasui, T., Tezuka, M., Ushigoe, K., Yamano, S., Kamada, M., Aono, T. Methods and findings in experimental and clinical pharmacology. (2000) [Pubmed]
 
WikiGenes - Universities