Paracrine VEGF/VE-Cadherin Action on Ovarian Cancer Permeability.
Ascites formation associated with neoplasms is most likely due to increased vascular permeability, a process in which vascular endothelial growth factor/vascular permeability factor (VEGF/ VPF) plays a pivotal role. We hypothesized that tumor-derived VEGF/ VPF modulates ascites formation through a paracrine effect on both tumor and peritoneal vessels. We investigated human vascular endothelial permeability using a newly developed dual-chamber permeability assay by co-culturing human umbilical vein cells with and without ovarian cancer cell lines (OVCAR-3, Hey-A8, and OCC-1) in the presence or absence of a human VEGF monoclonal antibody and VE-cadherin function-blocking antibody. This method permits determination of mechanisms by which substances released from neoplasms and other sources of vascular endothelial cell secretagogues modulate vascular permeability and likely other pathologic states.[1]References
- Paracrine VEGF/VE-Cadherin Action on Ovarian Cancer Permeability. Hu, L., Ferrara, N., Jaffe, R.B. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
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