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Chemical Compound Review

Action     methyl2-[2-chloro-4-fluoro-5- [(7-oxo-8...

Synonyms: SureCN39080, SureCN8437784, SureCN9048322, HSDB 7270, AC1L3QET, ...
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Disease relevance of C10908


Psychiatry related information on C10908

  • Implementing the National Arthritis Action Plan: new population-based approaches to increasing physical activity among people with arthritis [6].
  • The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press] [7].
  • RESULTS: The Stanford Nutrition Action Program classes showed significantly greater net improvements in nutrition knowledge (+7.7), attitudes (/0.2), and self-efficacy (-0.2) than the general nutrition classes; they also showed significantly greater reductions in the percentage of calories from total (-2.3%) and saturated (-0.9%) fat [8].
  • The 2004 National Action Plan for Tobacco Cessation recommended that the US Department of Health and Human Services convene a diverse group of experts to ensure that competency in tobacco dependence interventions be a core graduation requirement for all new physicians and other key health care professionals [9].
  • CONCLUSIONS: Anti-tobacco media campaigns are a vital component of the National Action Plan for Tobacco Cessation [10].

High impact information on C10908


Chemical compound and disease context of C10908


Biological context of C10908


Anatomical context of C10908


Associations of C10908 with other chemical compounds


Gene context of C10908

  • Concerted Action of Exonuclease and Gap-dependent Endonuclease Activities of FEN-1 Contributes to the Resolution of Triplet Repeat Sequences (CTG)n- and (GAA)n-derived Secondary Structures Formed during Maturation of Okazaki Fragments [36].
  • The International Consensus Meeting on the Mode of Action of COX-2 Inhibition (ICMMAC) brought together 17 international experts in arthritis, gastroenterology and pharmacology on 5 6 December 1997 [37].
  • The Concerted Action Polyp Prevention (CAPP) 1 Study is using a 2 x 2 factorial design to test the efficacy of resistant starch (30 g raw potato starch-Hylon VII (1:1, w/w)/d) and aspirin (600 mg/d) in suppressing colo-rectal adenoma formation in young subjects with FAP [38].
  • Using the multiplex PCR tubes of the BIOMED-2 Concerted Action, TCRB gene rearrangements were detected in 35% of childhood (n=161) and adult (n=172) precursor-B-ALL patients (Vbeta-(Dbeta)-Jbeta in 25%; Dbeta-Jbeta in 15%) [39].
  • The Committee of the European Concerted Action for Multiple Sclerosis (Charcot Foundation) organised five workshops to discuss CSF analytical standards in the diagnosis of multiple sclerosis [40].

Analytical, diagnostic and therapeutic context of C10908


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  4. Letter: Action of hepatitis-B antigen on Nicotiana sylvestris and Vigna sinensis. Dhalival, A.S., Rubinstein, H.M., Dietz, A.A. Lancet (1975) [Pubmed]
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  6. Implementing the National Arthritis Action Plan: new population-based approaches to increasing physical activity among people with arthritis. Brady, T.J., Sniezek, J.E. Arthritis Rheum. (2003) [Pubmed]
  7. Imaging a cognitive model of apraxia: the neural substrate of gesture-specific cognitive processes. Peigneux, P., Van der Linden, M., Garraux, G., Laureys, S., Degueldre, C., Aerts, J., Del Fiore, G., Moonen, G., Luxen, A., Salmon, E. Human brain mapping. (2004) [Pubmed]
  8. The Stanford Nutrition Action Program: a dietary fat intervention for low-literacy adults. Howard-Pitney, B., Winkleby, M.A., Albright, C.L., Bruce, B., Fortmann, S.P. American journal of public health. (1997) [Pubmed]
  9. Tobacco control competencies for US medical students. Geller, A.C., Zapka, J., Brooks, K.R., Dube, C., Powers, C.A., Rigotti, N., O'Donnell, J., Ockene, J. American journal of public health. (2005) [Pubmed]
  10. Impact of smoking cessation AIDS and mass media among recent quitters. Biener, L., Reimer, R.L., Wakefield, M., Szczypka, G., Rigotti, N.A., Connolly, G. American journal of preventive medicine. (2006) [Pubmed]
  11. Campaign contributions from the American Medical Political Action Committee to Members of Congress. For or against the public health? Sharfstein, J.M., Sharfstein, S.S. N. Engl. J. Med. (1994) [Pubmed]
  12. Genomic imprinting. Action at a distance. Eden, S., Cedar, H. Nature (1995) [Pubmed]
  13. Microbiology. Action at a distance--bacterial flagellar assembly. Macnab, R.M. Science (2000) [Pubmed]
  14. Sympathetic control of lower esophageal sphincter function in the cat. Action of direct cervical and splanchnic nerve stimulation. Fournet, J., Snape, W.J., Cohen, S. J. Clin. Invest. (1979) [Pubmed]
  15. Early Lung Cancer Action Project. Drury, N.E., Brown, I., Dalrymple-Hay, M.J., Delany, D.J., Halson, P. Lancet (1999) [Pubmed]
  16. Anion manipulation: a new antiarrhythmic approach. Action of substitution of chloride with nitrate on ischemia- and reperfusion-induced ventricular fibrillation and contractile function. Ridley, P.D., Curtis, M.J. Circ. Res. (1992) [Pubmed]
  17. Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells. Keum, Y.S., Yu, S., Chang, P.P., Yuan, X., Kim, J.H., Xu, C., Han, J., Agarwal, A., Kong, A.N. Cancer Res. (2006) [Pubmed]
  18. Ciz1, a Novel DNA-Binding Coactivator of the Estrogen Receptor {alpha}, Confers Hypersensitivity to Estrogen Action. den Hollander, P., Rayala, S.K., Coverley, D., Kumar, R. Cancer Res. (2006) [Pubmed]
  19. Protective immune mechanisms to ticks and tick-borne diseases of ruminants. Preston, P.M., Jongejan, F. Parasitol. Today (Regul. Ed.) (1999) [Pubmed]
  20. Structure and Action of the Binary C2 Toxin from Clostridium botulinum. Schleberger, C., Hochmann, H., Barth, H., Aktories, K., Schulz, G.E. J. Mol. Biol. (2006) [Pubmed]
  21. Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements. Bouchard, R.A., Clark, R.B., Giles, W.R. Circ. Res. (1995) [Pubmed]
  22. A Cooperative Action of the ATP-Dependent Import Motor Complex and the Inner Membrane Potential Drives Mitochondrial Preprotein Import. Krayl, M., Lim, J.H., Martin, F., Guiard, B., Voos, W. Mol. Cell. Biol. (2007) [Pubmed]
  23. Letter: Action of heparin in blood coagulation. Machovich, R. Blood (1975) [Pubmed]
  24. Cross-Talk between Nucleotide Excision and Homologous Recombination DNA Repair Pathways in the Mechanism of Action of Antitumor Trabectedin. Herrero, A.B., Martín-Castellanos, C., Marco, E., Gago, F., Moreno, S. Cancer Res. (2006) [Pubmed]
  25. Steady-state Kinetics and Inhibitory Action of Antitubercular Phenothiazines on Mycobacterium tuberculosis Type-II NADH-Menaquinone Oxidoreductase (NDH-2). Yano, T., Li, L.S., Weinstein, E., Teh, J.S., Rubin, H. J. Biol. Chem. (2006) [Pubmed]
  26. Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit. Girouard, S.D., Pastore, J.M., Laurita, K.R., Gregory, K.W., Rosenbaum, D.S. Circulation (1996) [Pubmed]
  27. Glycoprotein biosynthesis: studies on thyroid mannosyltransferases. I. Action on glycopeptides and simple glycosides. Adamany, A.M., Spiro, R.G. J. Biol. Chem. (1975) [Pubmed]
  28. Progesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein. Sadler, S.E., Maller, J.L. J. Biol. Chem. (1981) [Pubmed]
  29. Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes. Miyoshi, H., Perfield, J.W., Souza, S.C., Shen, W.J., Zhang, H.H., Stancheva, Z.S., Kraemer, F.B., Obin, M.S., Greenberg, A.S. J. Biol. Chem. (2007) [Pubmed]
  30. Collaborative Action of NF-{kappa}B and p38 MAPK Is Involved in CpG DNA-Induced IFN-{alpha} and Chemokine Production in Human Plasmacytoid Dendritic Cells. Osawa, Y., Iho, S., Takauji, R., Takatsuka, H., Yamamoto, S., Takahashi, T., Horiguchi, S., Urasaki, Y., Matsuki, T., Fujieda, S. J. Immunol. (2006) [Pubmed]
  31. Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis. Taylor, M.J., Freemantle, N., Geddes, J.R., Bhagwagar, Z. Arch. Gen. Psychiatry (2006) [Pubmed]
  32. 4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans. Cohen, S.M., Boobis, A.R., Bette Meek, M.E., Preston, R.J., McGregor, D.B. Crit. Rev. Toxicol. (2006) [Pubmed]
  33. Thiazopyr and Thyroid Disruption: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action. Dellarco, V.L., McGregor, D., Berry, S.C., Cohen, S.M., Boobis, A.R. Crit. Rev. Toxicol. (2006) [Pubmed]
  34. Formaldehyde and Glutaraldehyde and Nasal Cytotoxicity: Case Study Within the Context of the 2006 IPCS Human Framework for the Analysis of a Cancer Mode of Action for Humans. McGregor, D., Bolt, H., Cogliano, V., Richter-Reichhelm, H.B. Crit. Rev. Toxicol. (2006) [Pubmed]
  35. Inhibition by angiotensin II of baroreceptor-evoked activity in cardiac vagal efferent nerves in the dog. Lumbers, E.R., McCloskey, D.I., Potter, E.K. J. Physiol. (Lond.) (1979) [Pubmed]
  36. Concerted Action of Exonuclease and Gap-dependent Endonuclease Activities of FEN-1 Contributes to the Resolution of Triplet Repeat Sequences (CTG)n- and (GAA)n-derived Secondary Structures Formed during Maturation of Okazaki Fragments. Singh, P., Zheng, L., Chavez, V., Qiu, J., Shen, B. J. Biol. Chem. (2007) [Pubmed]
  37. Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. Brooks, P., Emery, P., Evans, J.F., Fenner, H., Hawkey, C.J., Patrono, C., Smolen, J., Breedveld, F., Day, R., Dougados, M., Ehrich, E.W., Gijon-Baños, J., Kvien, T.K., Van Rijswijk, M.H., Warner, T., Zeidler, H. Rheumatology (Oxford, England) (1999) [Pubmed]
  38. Can resistant starch and/or aspirin prevent the development of colonic neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 Study. Mathers, J.C., Mickleburgh, I., Chapman, P.C., Bishop, D.T., Burn, J. The Proceedings of the Nutrition Society. (2003) [Pubmed]
  39. TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse. van der Velden, V.H., Brüggemann, M., Hoogeveen, P.G., de Bie, M., Hart, P.G., Raff, T., Pfeifer, H., Lüschen, S., Szczepański, T., van Wering, E.R., Kneba, M., van Dongen, J.J. Leukemia (2004) [Pubmed]
  40. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. Andersson, M., Alvarez-Cermeño, J., Bernardi, G., Cogato, I., Fredman, P., Frederiksen, J., Fredrikson, S., Gallo, P., Grimaldi, L.M., Grønning, M. J. Neurol. Neurosurg. Psychiatr. (1994) [Pubmed]
  41. Impact of a short course in pharmacotherapy for undergraduate medical students: an international randomised controlled study. de Vries, T.P., Henning, R.H., Hogerzeil, H.V., Bapna, J.S., Bero, L., Kafle, K.K., Mabadeje, A., Santoso, B., Smith, A.J. Lancet (1995) [Pubmed]
  42. Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial. Kwakkel, G., Wagenaar, R.C., Twisk, J.W., Lankhorst, G.J., Koetsier, J.C. Lancet (1999) [Pubmed]
  43. Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP). Carreño, V., Marcellin, P., Hadziyannis, S., Salmerón, J., Diago, M., Kitis, G.E., Vafiadis, I., Schalm, S.W., Zahm, F., Manzarbeitia, F., Jiménez, F.J., Quiroga, J.A. Hepatology (1999) [Pubmed]
  44. Facial expressiveness in patients with schizophrenia compared to depressed patients and nonpatient comparison subjects. Trémeau, F., Malaspina, D., Duval, F., Corrêa, H., Hager-Budny, M., Coin-Bariou, L., Macher, J.P., Gorman, J.M. The American journal of psychiatry. (2005) [Pubmed]
  45. Managed care organization and the quality of diabetes care: the Translating Research Into Action for Diabetes (TRIAD) study. Kim, C., Williamson, D.F., Mangione, C.M., Safford, M.M., Selby, J.V., Marrero, D.G., Curb, J.D., Thompson, T.J., Narayan, K.M., Herman, W.H. Diabetes Care (2004) [Pubmed]
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