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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HTLV-I-associated myelopathy in a Californian: diagnosis by reactivity to a viral recombinant antigen.

A male patient developed leg numbness and weakness, and bowel, bladder, and erectile dysfunction. Examination revealed an isolated thoracic myelopathy, with lower-extremity spasticity, decreased vibration and position sense, hyperreflexia, and Babinski's signs. Serum and CSF showed antibody reactivity to human T-cell lymphotropic virus type I or II (HTLV-I/II), suggesting HTLV-I-associated myelopathy. Antibody reactivity to a unique HTLV-I recombinant protein provided definitive diagnosis of HTLV-I infection.[1]

References

  1. HTLV-I-associated myelopathy in a Californian: diagnosis by reactivity to a viral recombinant antigen. Honig, L.S., Lipka, J.J., Young, K.Y., Weiss, J.H., Foung, S.K. Neurology (1991) [Pubmed]
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