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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

HRX  -  Hyperreflexia

Homo sapiens

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Disease relevance of HRX


Psychiatry related information on HRX


High impact information on HRX


Chemical compound and disease context of HRX


Biological context of HRX


Anatomical context of HRX


Associations of HRX with chemical compounds

  • Although no single sign distinguished the groups, patients with mutations had significantly earlier and more symmetrical onset, dystonia more often at onset and hyperreflexia, slower progression of the disease, and a tendency toward a greater response to levodopa despite lower doses [30].
  • In 2 controlled trials, there was no significant difference between dantrolene and diazepam in terms of reductions in spasticity, clonus, and hyperreflexia, but side-effects such as drowsiness and inco-ordination occurred significantly more frequently on diazepam [31].
  • EMDA of oxybutynin reduced detrusor hyperreflexia [32].
  • The use of intravesical oxybutynin chloride in patients with detrusor hypertonicity and detrusor hyperreflexia [33].
  • A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial [34].

Regulatory relationships of HRX


Other interactions of HRX


Analytical, diagnostic and therapeutic context of HRX


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  33. The use of intravesical oxybutynin chloride in patients with detrusor hypertonicity and detrusor hyperreflexia. Kasabian, N.G., Vlachiotis, J.D., Lais, A., Klumpp, B., Kelly, M.D., Siroky, M.B., Bauer, S.B. J. Urol. (1994) [Pubmed]
  34. A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial. Petersen, T., Jakobsen, J. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  35. Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. Kaidoh, K., Igawa, Y., Takeda, H., Yamazaki, Y., Akahane, S., Miyata, H., Ajisawa, Y., Nishizawa, O., Andersson, K.E. J. Urol. (2002) [Pubmed]
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