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Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma.

A simple, rapid, sensitive and specific liquid chromatography/tandem mass spectrometry method was developed and validated to quantify troxerutin in human plasma. The analyte and rutin, used as the internal standard, were analyzed on a Phenomenex Synergi Fusion RP column interfaced with a triple-quadrupole tandem mass spectrometer using positive electrospray ionization. Acetonitrile/water (20:80 v/v) was used as the isocratic mobile phase, with 0.1% formic acid in water. A simple sample preparation method of protein precipitation with perchloric acid was employed. The assay was linear over the concentration range 31.25-4000 pg/mL. Correlation coefficients generated by linear regression with a 1/x(2) weighting factor ranged from 0.9991 to 0.9996. The intra- and inter-day precision over the entire concentration range were less than 12.28%. The method was successfully applied to a pharmacokinetic study after oral administration of a 300 mg troxerutin drop pill to 18 healthy volunteers. Copyright (c) 2006 John Wiley & Sons, Ltd.[1]

References

  1. Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma. Liu, F., Xu, Y., Rui, L., Gao, S., Dong, H., Guo, Q. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
 
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