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Chemical Compound Review

PERCHLORIC ACID     perchloric acid

Synonyms: Perchlorsaeure, HClO4, ACMC-1BEIA, AG-H-03228, CHEMBL1161634, ...
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Disease relevance of perchloric acid


Psychiatry related information on perchloric acid


High impact information on perchloric acid


Chemical compound and disease context of perchloric acid


Biological context of perchloric acid

  • Cells grown in time-course incubates with [35S]-6MP were extracted with cold perchloric acid, and the buffered extracts were subjected to high-performance liquid cation-exchange chromatography prior to and after hydrolysis with alkaline phosphatase [19].
  • In vitro studies demonstrated a time-dependent uptake of [(18)F]-FLT, an efficient phosphorylation to the respective monophosphate and the incorporation of [(18)F]-FLT into the perchloric acid insoluble fraction in DoHH2 cells, indicating the incorporation of this tracer into the DNA [20].
  • This drop was accompanied by an increase in [C-3]/[C-4] glutamate ratio in perchloric acid extracts of the tumors, indicating an increase in the Kreb's cycle activity [21].
  • A partial weak cross-reaction was observed with a mixture of placental glycoprotein (perchloric acid extract), but this reaction was abolished by absorption of antisera with placental glycoprotein [22].
  • Brain metabolite contents and enrichments were determined from analyses of brain tissue perchloric acid extracts according to their post-mortem evolution kinetics [23].

Anatomical context of perchloric acid

  • (iv) The amounts of inorganic phosphate, nucleoside phosphates, and sugar phosphates are determined by solution-state NMR observation of the perchloric acid extract of the oocytes [24].
  • 3. Xenografts of LS174T cells (a human colon carcinoma cell line) grown in nude mice were solubilized, extracted with several chaotropic agents and treated with perchloric acid [25].
  • Fresh frozen testis tissue was homogenized in water and precipitated with 1.0 M perchloric acid [26].
  • The yield of soluble CEA activity following perchloric acid extraction averaged 10%, and in one cyst fluid, qualitative changes were noted in the soluble antigenic activity [27].
  • Unlike native CEA, all of the fecal antigens were very poorly soluble in perchloric acid and did not bind to concanavalin A, suggesting that they had undergone significant deglycosylation in the digestive tract [28].

Associations of perchloric acid with other chemical compounds

  • Phosphorus-31 nuclear magnetic resonance (31P NMR) analyses of perchloric acid extracts show that inorganic phosphate predominates in dauer larvae, whereas ATP and other high-energy metabolites are abundant within 6 hr after dauer larvae have been placed in food to initiate development [29].
  • The endogenous ribonucleotides in the perchloric acid extracts as well as 6-thiopurine nucleotides were separated and quantified with anion exchange high-performance liquid chromatography [30].
  • When the cells were extracted under conditions where the ATPase activity was negligible, the ethanol extracts had a 75% higher ATP/ADP ratio and a higher adenylate energy charge than perchloric acid extracts [31].
  • Fragmented spinach chloroplast membranes or subchloroplast particles were illuminated and rapidly mixed with [32P]orthophosphate and AMP at pH 7 for 10 ms to 60 s after which time perchloric acid was added to quench the reaction [32].
  • These new dinucleotides were purified from perchloric acid extracts of dormant cysts by ion exchange column chromatography and identified by means of chemical, spectrophotometric, and enzymatic analyses compared to commercially available compounds [33].

Gene context of perchloric acid

  • This protein, HMG D, shares most of the characteristics of vertebrate HMG proteins; it is extractable from nuclei with 0.35 M NaCl, is soluble in 5% perchloric acid, is relatively small (molecular weight of 12,000), has both a high basic (24%) and high acidic (24%) amino acid content, and is a DNA-binding protein [34].
  • These included carcinoembryonic antigen (CEA), normal cross-reacting antigen, Y-hapten glycoproteins, and perchloric acid extracts and glycolipid preparations from colorectal tumours [35].
  • This reactivity was abolished after absorption of the antiserum with a perchloric acid extract of human lung to remove cross-reacting antibodies against non-specific cross-reacting antigen (NCA); a procedure which did not affect the staining of colon carcinoma specimens [36].
  • The observation that only the 76 kDa Tn-glycoprotein remained in the 0.6 N perchloric acid-soluble fraction suggests that it could be a good candidate for mucin characterisation in this parasite [37].
  • The perchloric acid extracts were prepared from suspensions of cls11 mutant and wild-type cells incubated with [1,3-13C]glycerol or [2-13]acetate, and analyzed by 31P, 13C and 1H NMR [38].

Analytical, diagnostic and therapeutic context of perchloric acid


  1. 31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. Ugurbil, K., Rottenberg, H., Glynn, P., Shulman, R.G. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  2. Chemical and functional correlates of postischemic renal ATP levels. Stromski, M.E., Cooper, K., Thulin, G., Gaudio, K.M., Siegel, N.J., Shulman, R.G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Navon, G., Ogawa, S., Shulman, R.G., Yamane, T. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  4. Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. Aboagye, E.O., Bhujwalla, Z.M., Shungu, D.C., Glickson, J.D. Cancer Res. (1998) [Pubmed]
  5. Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro. Lehtimäki, K.K., Valonen, P.K., Griffin, J.L., Väisänen, T.H., Gröhn, O.H., Kettunen, M.I., Vepsäläinen, J., Ylä-Herttuala, S., Nicholson, J., Kauppinen, R.A. J. Biol. Chem. (2003) [Pubmed]
  6. 31P nuclear magnetic resonance studies of phosphoglyceride metabolism in developing and degenerating brain: preliminary observations. Pettegrew, J.W., Kopp, S.J., Minshew, N.J., Glonek, T., Feliksik, J.M., Tow, J.P., Cohen, M.M. J. Neuropathol. Exp. Neurol. (1987) [Pubmed]
  7. Protic acid (HClO4 supported on silica gel)-mediated synthesis of 2,3-unsaturated-O-glucosides and a chiral furan diol from 2,3-glycals. Agarwal, A., Rani, S., Vankar, Y.D. J. Org. Chem. (2004) [Pubmed]
  8. Decreased brain N-acetylaspartate in Huntington's disease. Dunlop, D.S., Mc Hale, D.M., Lajtha, A. Brain Res. (1992) [Pubmed]
  9. Interspecies variations in mammalian lens metabolites as detected by phosphorus-31 nuclear magnetic resonance. Kopp, S.J., Glonek, T., Greiner, J.V. Science (1982) [Pubmed]
  10. Detection of new cross-reacting carcinoembryonic antigen(s) on cultured tumor cells by mixed hemadsorption assay. Dent, P.B., Carrel, S., Mach, J.P. J. Natl. Cancer Inst. (1980) [Pubmed]
  11. Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. Goedert, M., Jakes, R. EMBO J. (1990) [Pubmed]
  12. Neuromodulin (GAP43): a neuronal protein kinase C substrate is also present in 0-2A glial cell lineage. Characterization of neuromodulin in secondary cultures of oligodendrocytes and comparison with the neuronal antigen. Deloulme, J.C., Janet, T., Au, D., Storm, D.R., Sensenbrenner, M., Baudier, J. J. Cell Biol. (1990) [Pubmed]
  13. Ribonucleoprotein staining of centrioles and kinetochores in newt lung cell spindles. Rieder, C.L. J. Cell Biol. (1979) [Pubmed]
  14. 31P NMR studies of Clostridium thermocellum. Mechanism of end product inhibition by ethanol. Herrero, A.A., Gomez, R.F., Roberts, M.F. J. Biol. Chem. (1985) [Pubmed]
  15. 31P NMR spectroscopy of Trypanosoma brucei, trypanosoma cruzi, and leishmania major. Evidence for high levels of condensed inorganic phosphates. Moreno, B., Urbina, J.A., Oldfield, E., Bailey, B.N., Rodrigues, C.O., Docampo, R. J. Biol. Chem. (2000) [Pubmed]
  16. Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain. Klunk, W.E., Xu, C., Panchalingam, K., McClure, R.J., Pettegrew, J.W. Neurobiol. Aging (1996) [Pubmed]
  17. Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats. Harvey, P.J., Gready, J.E., Yin, Z., Le Couteur, D.G., McLean, A.J. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  18. Glutathione, but not glutamine, is detected in 13C-NMR spectra of perchloric acid extracts from C6 glioma cells. Portais, J.C., Martin, M., Canioni, P., Merle, M. FEBS Lett. (1993) [Pubmed]
  19. Quantitation of intracellular metabolites of [35S]-6-mercaptopurine in L5178Y cells grown in time-course incubates. Breter, H.J., Zahn, R.K. Cancer Res. (1979) [Pubmed]
  20. 3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease. Wagner, M., Seitz, U., Buck, A., Neumaier, B., Schultheiss, S., Bangerter, M., Bommer, M., Leithäuser, F., Wawra, E., Munzert, G., Reske, S.N. Cancer Res. (2003) [Pubmed]
  21. Cyclophosphamide treatment modifies tumor oxygenation and glycolytic rates of RIF-1 tumors: 13C magnetic resonance spectroscopy, Eppendorf electrode, and redox scanning. Poptani, H., Bansal, N., Jenkins, W.T., Blessington, D., Mancuso, A., Nelson, D.S., Feldman, M., Delikatny, E.J., Chance, B., Glickson, J.D. Cancer Res. (2003) [Pubmed]
  22. Radioimmunoassay for tissue distribution of a human mammary tumor-specific glycoprotein. Leung, J.P., Edgington, T.S. Cancer Res. (1980) [Pubmed]
  23. Ex vivo analysis of lactate and glucose metabolism in the rat brain under different states of depressed activity. Serres, S., Bezancon, E., Franconi, J.M., Merle, M. J. Biol. Chem. (2004) [Pubmed]
  24. Combining solid-state and solution-state 31P NMR to study in vivo phosphorus metabolism. Cholli, A.L., Yamane, T., Jelinski, L.W. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  25. Purification and composition of the human tumor-associated glycoprotein (TAG-72) defined by monoclonal antibodies CC49 and B72.3. Sheer, D.G., Schlom, J., Cooper, H.L. Cancer Res. (1988) [Pubmed]
  26. Testis imaging with 111In-labeled anticarcinoembryonic antigen monoclonal antibody: identification of carcinoembryonic antigen in normal germ cells. Beatty, B.G., Paxton, R.J., Sheibani, K., Duda, R.B., Williams, L.E., Shively, J.E., Beatty, J.D. Cancer Res. (1986) [Pubmed]
  27. Characterization of the carcinoembryonic antigen activity associated with cyst fluids of mucinous ovarian cystadenocarcinoma. Yamashita, K., Aitio, M.L., Dawson, J.R. Cancer Res. (1979) [Pubmed]
  28. Identification and characterization of new antigenic fragments related to carcinoembryonic antigen in adult feces. Henslee, J.G., Vachula, E.J., Paxton, R.J., Matias, M.S., Shively, J.E., Rittenhouse, H.G., Tomita, J.T. Cancer Res. (1992) [Pubmed]
  29. Acidic intracellular pH shift during Caenorhabditis elegans larval development. Wadsworth, W.G., Riddle, D.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  30. On the paradoxically concentration-dependent metabolism of 6-mercaptopurine in WEHI-3b murine leukemia cells. Liliemark, J., Pettersson, B., Engberg, B., Lafolie, P., Masquelier, M., Peterson, C. Cancer Res. (1990) [Pubmed]
  31. Determination of the ADP concentration available to participate in energy metabolism in an actin-rich cell, the platelet. Daniel, J.L., Robkin, L., Molish, I.R., Holmsen, H. J. Biol. Chem. (1979) [Pubmed]
  32. Initial products of photophosphorylation with AMP and [32P]Pi. Horner, R.D., Froehlich, J.P., Moudrianakis, E.N. J. Biol. Chem. (1983) [Pubmed]
  33. The presence of guanosine 5'-diphospho-5'-guanosine and guanosine 5'-triphospho-5'-adenosine in brine shrimp embryos. Gilmour, S.J., Warner, A.H. J. Biol. Chem. (1978) [Pubmed]
  34. A high-mobility-group protein and its cDNAs from Drosophila melanogaster. Wagner, C.R., Hamana, K., Elgin, S.C. Mol. Cell. Biol. (1992) [Pubmed]
  35. Reactivity of an anti-(human gastric carcinoma) monoclonal antibody with core-related peptides of gastrointestinal mucin. Price, M.R., Sekowski, M., Yang, G.Y., Durrant, L.G., Robins, R.A., Baldwin, R.W. Cancer Immunol. Immunother. (1991) [Pubmed]
  36. Granular cell myoblastoma: an immunoperoxidase study using a variety of antisera to human carcinoembryonic antigen. Matthews, J.B., Mason, G.I. Histopathology (1983) [Pubmed]
  37. Mucin-type O-glycosylation in Fasciola hepatica: characterisation of carcinoma-associated Tn and sialyl-Tn antigens and evaluation of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity. Freire, T., Casaravilla, C., Carmona, C., Osinaga, E. Int. J. Parasitol. (2003) [Pubmed]
  38. A multinuclear magnetic resonance study of a cls11 mutant showing the Pet- phenotype of Saccharomyces cerevisiae. Galons, J.P., Tanida, I., Ohya, Y., Anraku, Y., Arata, Y. Eur. J. Biochem. (1990) [Pubmed]
  39. Membrane transport by murine lymphocytes. I. A rapid sampling technique as applied to the adenosine and thymidine systems. Strauss, P.R., Sheehan, J.M., Kashket, E.R. J. Exp. Med. (1976) [Pubmed]
  40. The zinc glycinate marker in human colon carcinoma. Pusztaszeri, G., Saravis, C.A., Zamcheck, N. J. Natl. Cancer Inst. (1976) [Pubmed]
  41. Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes. Cassimeris, L., Safer, D., Nachmias, V.T., Zigmond, S.H. J. Cell Biol. (1992) [Pubmed]
  42. Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens. Vrba, R., Alpert, E., Isselbacher, K.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
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