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Margarit, L. et al.

Lavinia Margarit, Anthony N. Griffiths, Vassilios Tsapanos, Sotiris Tsakas, Dimitios Gumenos, George Decavalas,

Second trimester amniotic fluid endothelin-1 concentrations and subsequent development of intrauterine growth restriction.

OBJECTIVE: The purpose of this prospective study was to record endothelin-1 (ET-1) concentrations in the second trimester amniotic fluid and compare these values in women who developed intrauterine growth restriction (IUGR) later in pregnancy with those with uneventful pregnancies. METHOD: Amniotic fluid was retrieved by amniocentesis from 125 women in the second trimester of pregnancy. The levels of ET1 were measured by a sensitive and specific radioimmunoassay. RESULTS: From the 125 women included in the study 12 had pregnancies that later developed IUGR and 88 had uneventful pregnancies. The ET1 concentration was significantly higher (P<0.005) in women who later developed IUGR than in normal pregnancy (106 pg/ml versus 64.7 pg/ml). CONCLUSION: The amniotic fluid concentration of ET1 is elevated by the second trimester in women who later develop IUGR.[1]

References

Second trimester amniotic fluid endothelin-1 concentrations and subsequent development of intrauterine growth restriction. Margarit, L., Griffiths, A.N., Tsapanos, V., Tsakas, S., Gumenos, D., Decavalas, G. Eur. J. Obstet. Gynecol. Reprod. Biol. (2007) [Pubmed]

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