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Disease relevance of Amniocentesis


High impact information on Amniocentesis

  • Between October 1984 and June 1987, we identified 22,748 pregnant women when they underwent screening either by measurement of maternal serum alpha-fetoprotein or by amniocentesis [6].
  • They were offered genetic counselling, parental and (if appropriate) CF carrier testing, and amniocentesis for karyotype and CF status if parents were informative [7].
  • Children of women who had amniocentesis had a significantly higher rate of haemolytic disease due to ABO isoimmunisation than matched controls [8].
  • Early amniocentesis and amniotic fluid AFP levels [9].
  • The prevalence of 45,X/46,XX mosaicism is 10-fold higher among amniocenteses than in series of postnatally diagnosed individuals with Turner syndrome, which suggests that most individuals with this karyotype escape detection and that an ascertainment bias exists toward those with clinically evident abnormalities [10].

Chemical compound and disease context of Amniocentesis


Biological context of Amniocentesis


Anatomical context of Amniocentesis


Associations of Amniocentesis with chemical compounds


Gene context of Amniocentesis


Analytical, diagnostic and therapeutic context of Amniocentesis


  1. Maternal serum alpha-fetoprotein measurement: a screening test for Down syndrome. Cuckle, H.S., Wald, N.J., Lindenbaum, R.H. Lancet (1984) [Pubmed]
  2. Maternal serum alpha-fetoprotein and spontaneous abortion. Wald, N., Barker, S., Cuckle, H., Brock, D.J., Stirrat, G.M. British journal of obstetrics and gynaecology. (1977) [Pubmed]
  3. The effect of maternal weight on maternal serum alpha-fetoprotein levels. Wald, N., Cuckle, H., Boreham, J., Terzian, E., Redman, C. British journal of obstetrics and gynaecology. (1981) [Pubmed]
  4. A normal ultrasound does not obviate the need for amniocentesis in patients with elevated serum alpha-fetoprotein. Drugan, A., Zador, I.E., Syner, F.N., Sokol, R.J., Sacks, A.J., Evans, M.I. Obstetrics and gynecology. (1988) [Pubmed]
  5. Amniotic fluid lipopolysaccharide-binding protein and soluble CD14 as mediators of the inflammatory response in preterm labor. Gardella, C., Hitti, J., Martin, T.R., Ruzinski, J.T., Eschenbach, D. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  6. Teratogenicity of high vitamin A intake. Rothman, K.J., Moore, L.L., Singer, M.R., Nguyen, U.S., Mannino, S., Milunsky, A. N. Engl. J. Med. (1995) [Pubmed]
  7. Prognostic implications of fetal echogenic bowel. Slotnick, R.N., Abuhamad, A.Z. Lancet (1996) [Pubmed]
  8. Population-based study of long-term outcomes after amniocentesis. Baird, P.A., Yee, I.M., Sadovnick, A.D. Lancet (1994) [Pubmed]
  9. Early amniocentesis and amniotic fluid AFP levels. Crandall, B.F., Hanson, F.W., Tennant, F. Lancet (1987) [Pubmed]
  10. Prenatal diagnosis of 45,X/46,XX mosaicism and 45,X: implications for postnatal outcome. Koeberl, D.D., McGillivray, B., Sybert, V.P. Am. J. Hum. Genet. (1995) [Pubmed]
  11. Amniocentesis for selection before rescue cerclage. Mays, J.K., Figueroa, R., Shah, J., Khakoo, H., Kaminsky, S., Tejani, N. Obstetrics and gynecology. (2000) [Pubmed]
  12. Prenatal diagnosis of neural tube defects: predictive value of AF-AFP in a low-risk population. Fisher, N.L., Luthy, D.A., Peterson, A., Karp, L.E., Williamson, R., Cheng, E. Am. J. Med. Genet. (1981) [Pubmed]
  13. Intra-amniotic injection of thyroxine (T4Y to a human fetus. Evidence for conversion of T4 to reverse T3. Lightner, E.S., Fismer, F.A., Giles, H., Woolfenden, J. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  14. Complete resolution of CMV-associated acute hydramnios by single large volume reduction amniocentesis and maternal indomethacin. A case report. Bondagji, N., Manning, F.A., Martel, J., Harman, C.R., Morrison, I. Fetal. Diagn. Ther. (1996) [Pubmed]
  15. Fetal death after exposure to methylene blue dye during mid-trimester amniocentesis in twin pregnancy. Kidd, S.A., Lancaster, P.A., Anderson, J.C., Boogert, A., Fisher, C.C., Robertson, R., Wass, D.M. Prenat. Diagn. (1996) [Pubmed]
  16. Application of flow karyotyping in prenatal detection of chromosome aberrations. Gray, J.W., Trask, B., van den Engh, G., Silva, A., Lozes, C., Grell, S., Schonberg, S., Yu, L.C., Golbus, M.S. Am. J. Hum. Genet. (1988) [Pubmed]
  17. The prenatal diagnosis of adrenoleukodystrophy. Demonstration of increased hexacosanoic acid levels in cultured amniocytes and fetal adrenal gland. Moser, H.W., Moser, A.B., Powers, J.M., Nitowsky, H.M., Schaumburg, H.H., Norum, R.A., Migeon, B.R. Pediatr. Res. (1982) [Pubmed]
  18. Elevated maternal serum alpha-fetoprotein caused by midtrimester amniocentesis: a prognostic factor. Thomsen, S.G., Isager-Sally, L., Lange, A.P., Saurbrey, N., Grønvall, S., Schiøler, V. Obstetrics and gynecology. (1983) [Pubmed]
  19. Amniotic fluid alpha-fetoprotein levels and pregnancy outcome. Brumfield, C.G., Cloud, G.A., Finley, S.C., Cosper, P., Davis, R.O., Huddleston, J.F. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  20. The use of the polymerase chain reaction to detect bacteria in amniotic fluid in pregnancies complicated by preterm labor. Markenson, G.R., Martin, R.K., Tillotson-Criss, M., Foley, K.S., Stewart, R.S., Yancey, M. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  21. A technic for the detection of rupture of the membranes. A review and preliminary report. Smith, R.P. Obstetrics and gynecology. (1976) [Pubmed]
  22. Fetal RhD genotyping from maternal plasma. Lo, Y.M. Ann. Med. (1999) [Pubmed]
  23. Periodic health examination, 1996 update: 1. Prenatal screening for and diagnosis of Down syndrome. Canadian Task Force on the Periodic Health Examination. Dick, P.T. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1996) [Pubmed]
  24. Detection of fetal risk in postmaturity. Homburg, R., Ludomirski, A., Insler, V. British journal of obstetrics and gynaecology. (1979) [Pubmed]
  25. Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. Bush, M.C., Gaddipati, S., Berkowitz, R. Obstetrics and gynecology. (2003) [Pubmed]
  26. Amniotic fluid insulin and C peptide levels in diabetic and nondiabetic women during early pregnancy. Fallucca, F., Sciullo, E., Napoli, A., Cardellini, G., Maldonato, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  27. Prenatal dexamethasone treatment in pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency: effect on midgestational amniotic fluid steroid levels. Dörr, H.G., Sippell, W.G. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  28. Profiling steroid hormones in amniotic fluid of midpregnancy by routine stable isotope dilution/gas chromatography-mass spectrometry: reference values and concentrations in fetuses at risk for 21-hydroxylase deficiency. Wudy, S.A., Dörr, H.G., Solleder, C., Djalali, M., Homoki, J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  29. A randomized trial of cerclage versus no cerclage among patients with ultrasonographically detected second-trimester preterm dilatation of the internal os. Rust, O.A., Atlas, R.O., Jones, K.J., Benham, B.N., Balducci, J. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  30. The ability of the chemiluminescence test to predict clinical outcome and the necessity for amniocenteses in pregnancies at risk of haemolytic disease of the newborn. Hadley, A.G., Wilkes, A., Goodrick, J., Penman, D., Soothill, P., Lucas, G. British journal of obstetrics and gynaecology. (1998) [Pubmed]
  31. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels in human amniotic fluid. Marx, C.E., Vance, B.J., Jarskog, L.F., Chescheir, N.C., Gilmore, J.H. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  32. Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions. Ohno, Y., Kasugai, M., Kurauchi, O., Mizutani, S., Tomoda, Y. Eur. J. Endocrinol. (1994) [Pubmed]
  33. Antenatal detection of neural tube defects: comparison of biochemical and immunofluorescence methods. Bell, J.E., Barron, L., Raab, G. Prenat. Diagn. (1994) [Pubmed]
  34. Elevated monocyte chemotactic protein-1 in amniotic fluid is a risk factor for pregnancy loss. Chaiworapongsa, T., Romero, R., Tolosa, J.E., Yoshimatsu, J., Espinoza, J., Kim, Y.M., Kim, J.C., Bujold, E., Kalache, K., Edwin, S. J. Matern. Fetal. Neonatal. Med. (2002) [Pubmed]
  35. Absence of need for amniocentesis in patients with elevated levels of maternal serum alpha-fetoprotein and normal ultrasonographic examinations. Nadel, A.S., Green, J.K., Holmes, L.B., Frigoletto, F.D., Benacerraf, B.R. N. Engl. J. Med. (1990) [Pubmed]
  36. Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency. Spector, E.B., Kiernan, M., Bernard, B., Cederbaum, S.D. Am. J. Hum. Genet. (1980) [Pubmed]
  37. A controlled retrospective follow-up study of the impact of genetic counseling on parental reproduction following the birth of a Down syndrome child. Oetting, L.A., Steele, M.W. Clin. Genet. (1982) [Pubmed]
  38. Risks associated with an elevated maternal serum alpha-fetoprotein level. Crandall, B.F., Robinson, L., Grau, P. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  39. Tocolysis with advanced cervical dilatation. Amon, E., Midkiff, C., Winn, H., Holcomb, W., Shumway, J., Artal, R. Obstetrics and gynecology. (2000) [Pubmed]
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