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Yao, Q. et al.

Peroxisome Proliferator-Activated Receptor-gamma Agonists Diminish Peritoneal Functional and Morphological Changes Induced by Bioincompatible Peritoneal Dialysis Solution.

Background: To evaluate if peroxisome proliferator-activated receptor-gamma ( PPAR-gamma) agonists have a potential protective effect on the peritoneum changes induced by bioincompatible peritoneal dialysis (PD) solution in vivo. Methods: Male Wistar rats were dialyzed three times daily for 28 days with 1.36% Dianeal(R) (two groups: with (D+R) or without (D) rosiglitazone) or 1.36% Physioneal(R) (two groups: with (P+R) or without (P) rosiglitazone). Peritoneal transport of fluid and small solutes was assessed. Nine rats that did not receive dialysis served as controls. Results: Significant morphological changes were found in the D group compared with controls. Additional use of rosiglitazone in the D+R group resulted in less morphological changes and expression of collagen I as well as an increased drainage volume. The expression of VEGF was inhibited by rosiglitazone while no apparent effect was found regarding TGF/Smad pathway. Conclusions: The addition of rosiglitazone to standard dialysis fluids can maintain the peritoneal morphology and increase ultrafiltration in a PD rat model. Copyright (c) 2006 S. Karger AG, Basel.[1]

References

Peroxisome Proliferator-Activated Receptor-gamma Agonists Diminish Peritoneal Functional and Morphological Changes Induced by Bioincompatible Peritoneal Dialysis Solution. Yao, Q., Pawlaczyk, K., Ayala, E.R., Kuzlan, M., Styszynski, A., Breborowicz, A., Heimburger, O., Qian, J., Stenvinkel, P., Axelsson, J., Lindholm, B. Blood Purif. (2006) [Pubmed]

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