Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm.
Previous data showed that complexin I, a SNARE regulatory protein, is localized in and/or around the acrosome and is necessary for the acrosome reaction in sperm. To understand how complexin I regulates the acrosome reaction, we used complexin-GST pulldown assays to identify interacting proteins. We showed that both complexins I and II bound mouse sperm dynamin 2. Dynamin 2 is a 100 kDa GTPase essential to many aspects of endocytosis but its potential role in exocytosis is unknown. Dynamin 2 is expressed in rat testis and widely expressed in other tissues; however, the function of dynamin 2 in germ cells is uncertain. Dynamin 2 protein was detected in mouse testis and was most abundant in or around the developing acrosome of spermatids. In addition, dynamin 2 was co-localized with complexin I in the acrosomal region of mammalian sperm. Its co-localization and interaction with complexin I suggest that dynamin 2 may play a role during acrosome formation and/or acrosomal exocytosis. Mol. Reprod. Dev. 74: 750-757, 2007. (c) 2006 Wiley-Liss, Inc.[1]References
- Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm. Zhao, L., Shi, X., Li, L., Miller, D.J. Mol. Reprod. Dev. (2007) [Pubmed]
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