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Gene Review

Dnm2  -  dynamin 2

Mus musculus

Synonyms: Dyn2, Dynamin UDNM, Dynamin-2, Udnm, b2b2159Clo
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High impact information on Dnm2


Biological context of Dnm2


Anatomical context of Dnm2

  • To define how Dyn2 might participate in actin dynamics in livings cells we have expressed green fluorescent protein (GFP)-tagged Dyn2 in cultured cells and observed labeling of comet-like vesicles and macropinosomes [7].
  • To determine the role of caveolae internalization in the mechanism of NO production, we expressed dominant-negative dynamin-2 mutant (K44A) or treated cells with methyl-beta-cyclodextrin [8].
  • Therefore, we examined etorphine and morphine effects on regulation of GRK-2 and DYN-2 in mouse spinal cord [9].
  • Dynamin 2 protein was detected in mouse testis and was most abundant in or around the developing acrosome of spermatids [6].

Associations of Dnm2 with chemical compounds

  • Delivery of the same daily dose of etorphine or naloxone using intermittent (every 24 h for 7 days) s.c. administration had no effect on immunoreactive mu-opioid receptor, [3H] DAMGO binding or dynamin-2 abundance [4].

Other interactions of Dnm2

  • Thus, dynamin 2 may be the constitutive counterpart of dynamin 1 in growing neurons [10].
  • The large GTPase dynamin (Dyn2) has been demonstrated by us and others to interact with several different actin-binding proteins [7].
  • Etorphine increased ( approximately 70%) DYN-2 protein abundance and decreased its mRNA (31%), whereas it had no effect on GRK-2 protein and mRNA abundance [9].


  1. Dynamin 2 is required for phagocytosis in macrophages. Gold, E.S., Underhill, D.M., Morrissette, N.S., Guo, J., McNiven, M.A., Aderem, A. J. Exp. Med. (1999) [Pubmed]
  2. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Tzingounis, A.V., Nicoll, R.A. Neuron (2006) [Pubmed]
  3. Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization. del Pozo, M.A., Balasubramanian, N., Alderson, N.B., Kiosses, W.B., Grande-García, A., Anderson, R.G., Schwartz, M.A. Nat. Cell Biol. (2005) [Pubmed]
  4. Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo. Yoburn, B.C., Purohit, V., Patel, K., Zhang, Q. Eur. J. Pharmacol. (2004) [Pubmed]
  5. Antagonist-induced micro-opioid receptor up-regulation decreases G-protein receptor kinase-2 and dynamin-2 abundance in mouse spinal cord. Patel, M., Gomes, B., Patel, C., Yoburn, B.C. Eur. J. Pharmacol. (2002) [Pubmed]
  6. Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm. Zhao, L., Shi, X., Li, L., Miller, D.J. Mol. Reprod. Dev. (2007) [Pubmed]
  7. The large GTPase dynamin regulates actin comet formation and movement in living cells. Orth, J.D., Krueger, E.W., Cao, H., McNiven, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells. Maniatis, N.A., Brovkovych, V., Allen, S.E., John, T.A., Shajahan, A.N., Tiruppathi, C., Vogel, S.M., Skidgel, R.A., Malik, A.B., Minshall, R.D. Circ. Res. (2006) [Pubmed]
  9. Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo. Patel, M.B., Patel, C.N., Rajashekara, V., Yoburn, B.C. Mol. Pharmacol. (2002) [Pubmed]
  10. Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study. Grabs, D., Bergmann, M. Cell Tissue Res. (2005) [Pubmed]
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